Tetracaine 4% gel
Available from a pharmacy with pharmacist advice
Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Tetracaine
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Tetracaine
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Tetracaine on the MHRA register
Ametop 4% gel
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 7 · Randomised trials: 14 · 1980–2026
Showing the 50 most relevant studies, sorted by most relevant.
B. Lemyre, Rebecca Sherlock, Debora L Hogan, et al.
BMC Medicine, 2006
Darioush Moradi Farsani, Seyed Ehsan Shakerinia
Advanced Biomedical Research, 2024
W. Kim, B. Song, H. Kil
Korean Journal of Anesthesiology, 2012
B. Lemyre, Debora L Hogan, I. Gaboury, et al.
BMC Pediatrics, 2007
S. Shipman, K. Painter, M. Keuchel, et al.
Annals of emergency medicine, 2020
A. Singer, Mary Jo Stark
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2000
N. Waldman, Ian K Densie, P. Herbison
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2014
Atsuo Yamashita, M. Matsumoto, S. Matsumoto, et al.
Anesthesia & Analgesia, 2003
M. Ballantyne, E. Ung, S. Gibbins, et al.
Advances in Neonatal Care, 2003
Hossein Madineh, Soroush Amani, Majid Kabiri, et al.
Journal of Advanced Pharmaceutical Technology & Research, 2017
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
1 found
Half-life
Not available
Mechanism
Tetracaine is an ester-type anesthetic and produces local anesthesia by blocking…
Food interactions
None known
Human targets
4 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
0.9 ng/mL
Half-life
Protein binding
Volume of distribution
Metabolism
Clearance
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 1622 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:11741831 PMID:16163667 PMID:18268335 PMID:18650434 PMID:26115329
Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm .
PMID:18268335
Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity)
The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development
The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues .
PMID:15385606 PMID:16988069 PMID:17145499 PMID:17167479 PMID:19369487 PMID:24311784 PMID:25240195 PMID:26680203 PMID:7720699
Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain PMID:17145499 PMID:17167479 PMID:19369487 PMID:24311784
ATC C05AD02
ATC N01BA03
ATC D04AB06
ATC N01BA53
ATC S01HA03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Tetracaine
Additional database identifiers
Drugs Product Database (DPD)
6788
Drugs Product Database (DPD)
2958
ChemSpider
5218
BindingDB
50017659
PDB
TE4
ZINC
ZINC000001530811
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10483
GenAtlas
RYR1
GeneCards
RYR1
GenBank Gene Database
J05200
GenBank Protein Database
337722
UniProt Accession
RYR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10484
GeneCards
RYR2
Guide to Pharmacology
748
UniProt Accession
RYR2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10585
GenAtlas
SCN1A
GeneCards
SCN1A
GenBank Gene Database
AF225985
GenBank Protein Database
12642270
Guide to Pharmacology
578
UniProt Accession
SCN1A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10582
GenAtlas
SCN10A
GeneCards
SCN10A
GenBank Gene Database
AF117907
GenBank Protein Database
4838145
Guide to Pharmacology
585
UniProt Accession
SCNAA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10583
GenAtlas
SCN11A
GeneCards
SCN11A
GenBank Gene Database
AF188679
GenBank Protein Database
6572950
UniProt Accession
SCNBA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10588
GenAtlas
SCN2A
GeneCards
SCN2A
GenBank Gene Database
M94055
GenBank Protein Database
457879
Guide to Pharmacology
579
UniProt Accession
SCN2A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10590
GenAtlas
SCN3A
GeneCards
SCN3A
GenBank Gene Database
AJ251507
GenBank Protein Database
7414320
Guide to Pharmacology
580
UniProt Accession
SCN3A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10591
GenAtlas
SCN4A
GeneCards
SCN4A
GenBank Gene Database
M81758
GenBank Protein Database
338213
Guide to Pharmacology
581
UniProt Accession
SCN4A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10593
GenAtlas
SCN5A
GeneCards
SCN5A
GenBank Gene Database
M77235
GenBank Protein Database
184039
Guide to Pharmacology
582
UniProt Accession
SCN5A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10594
GeneCards
SCN7A
UniProt Accession
SCN7A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10596
GenAtlas
SCN8A
GeneCards
SCN8A
GenBank Gene Database
AF050736
GenBank Protein Database
4321647
Guide to Pharmacology
583
UniProt Accession
SCN8A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10597
GenAtlas
SCN9A
GeneCards
SCN9A
GenBank Gene Database
X82835
GenBank Protein Database
758110
Guide to Pharmacology
584
UniProt Accession
SCN9A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10582
GenAtlas
SCN10A
GeneCards
SCN10A
GenBank Gene Database
AF117907
GenBank Protein Database
4838145
Guide to Pharmacology
585
UniProt Accession
SCNAA_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q419608), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.