Sodium hypochlorite 2% solution
Hypochlorite is an ion composed of chlorine and oxygen with the chemical formula ClO−.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Sodium hypochlorite
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Sodium hypochlorite
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 22 · Randomised trials: 18 · 1983–2026
Showing the 50 most relevant studies, sorted by most relevant.
Kasidid Ruksakiet, Lilla Hanák, Nelli Farkas, et al.
Journal of Endodontics, 2020
Lúcio Souza Gonçalves, Renata Costa Val Rodrigues, Carlos Vieira Andrade, et al.
Journal of Endodontics, 2016
- Anti-Infective Agents
- Bacteria
- Chlorhexidine
Maud Guivarc’h, Ugo Ordioni, Hany Mohamed Aly Ahmed, et al.
Journal of Endodontics, 2016
- Root Canal Irrigants
- Sodium Hypochlorite
- Root Canal Preparation
Carlos Estrela, Júlio Almeida Silva, Ana Helena Gonçalves de Alencar, et al.
Journal of Applied Oral Science, 2008
- Bacteriological Techniques
- Chlorhexidine
- Dental Pulp Cavity
Neha Verma, Pankaj Sangwan, Sanjay Tewari, et al.
Journal of Endodontics, 2019
- Root Canal Therapy
- Chronic Disease
- Dental Pulp Necrosis
Cakici F, Cakici EB
2024
- Sodium Hypochlorite
- Chitosan
- Root Canal Irrigants
Teja KV, Vasundhara KA, Patini R, et al.
2026
- Sodium Hypochlorite
- Root Canal Irrigants
- Root Canal Therapy
Aucinaite R, Nedzinskiene E, Peciuliene V, et al.
2025
Zhou W, Feng S, Chu X, et al.
2025
Yuan Qiu, Jiawei Xu, Yuedan Xu, et al.
PeerJ, 2023
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Sodium hypochlorite mediate its antimicrobial action by reacting with fatty acids and amino acids.
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Half-life
Protein binding
Volume of distribution
Metabolism
Elimination
Clearance
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
How the body processes this drug — absorption, distribution, metabolism, and elimination
ATC D08AX07
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
DrugBank citations
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q407204), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.