Prilocaine 50mg/10ml solution for injection ampoules

ObjectivesTo determine if tolerance of intravenous catheterisation differs following the application of vapocoolant spray compared to lidocaine/prilocaine cream in dogs and cats.Materials and methodsA randomised controlled trial of client-owned dogs and cats requiring intravenous catheterisation was performed. They were randomly allocated to either have lidocaine/prilocaine cream applied to their skin 1 hour prior to intravenous catheterisation or a swab saturated with vapocoolant spray applied immediately prior to intravenous catheterisation. The procedure was video-recorded and a single blinded observer reviewed the recordings and assigned reaction scores (0 to 3) at 4 time points (initial restraint, limb handling, swab application and skin puncture).ResultsBetween October 2020 and March 2022, a total of 101 animals (83 dogs and 18 cats) were enrolled, with 56 patients randomised to receive vapocoolant spray and 45 to receive lidocaine/prilocaine cream. There was no significant difference in the age, sex status, number of cross and pure breeds, and mentation detected between the groups. There was no significant difference in reaction scores between the treatments when comparing all patients at any time point except for a significantly increased swab application reaction score in patients receiving vapocoolant spray. Vapocoolant spray was significantly less effective in reducing adverse reaction to skin puncture than lidocaine/prilocaine cream in the small number of cats evaluated.Clinical significanceWhen considering all patients together, no single method of anaesthesia appeared superior for improving tolerance of intravenous catheter placement. However, vapocoolant spray may be less effective than lidocaine/prilocaine cream in reducing adverse response to skin puncture during catheterisation in cats.

Abstract licence: CC BY

BackgroundEffective pain management is essential for enhancing patient satisfaction and treatment compliance during facial rejuvenation procedures. Compound lidocaine cream and lidocaine-prilocaine cream are commonly used topical anesthetics in clinical practice; however, high-quality randomized controlled trials directly comparing their analgesic efficacy and safety in facial rejuvenation remain limited.ObjectiveThis study aimed to compare the analgesic efficacy and safety of compound lidocaine cream and lidocaine-prilocaine cream in patients undergoing facial rejuvenation procedures.MethodsThis single-center, prospective, randomized controlled trial enrolled 100 patients undergoing facial rejuvenation between January 2024 and June 2025. Participants were randomly assigned to receive either compound lidocaine cream (n = 47) or lidocaine-prilocaine cream (n = 53). The primary outcome was procedural pain intensity, assessed using a 10-point visual analog scale (VAS). Secondary outcomes included the incidence of adverse reactions, patient satisfaction, and treatment compliance.ResultsBaseline characteristics were comparable between the two groups (p > 0.05). The mean pain score was significantly lower in the compound lidocaine cream group than in the lidocaine-prilocaine cream group (2.51 ± 1.80 vs. 3.75 ± 1.74; t = -3.48, p 2 = 1.89, p = 0.169).ConclusionCompound lidocaine cream demonstrated superior analgesic efficacy in this clinical comparison; however, differences in anesthetic concentration, application technique, and lack of participant blinding should be considered when interpreting these findings. Larger studies with standardized dosing and blinding are warranted.

Abstract licence: CC BY