Polysaccharide-iron complex 100mg/5ml oral solution sugar free

Bletilla striata polysaccharide (BSP), a bioactive glucomannan derived from the traditional Chinese medicinal herb Bletilla striata, has garnered increasing attention in both the biomedical and food sectors due to its unique physicochemical properties and diverse biological activities. While existing reviews have partially covered BSP's structural features or single-field applications, a systematic review integrating its structure-activity relationship, full-spectrum chemical modification strategies, and parallel advances in the dual core fields of biomedicine and the food industry remains lacking. This review systematically consolidates recent advances in BSP research, focusing on three interconnected aspects: (1) the structure-activity relationships of BSP, highlighting how molecular weight (104-105 Da), monosaccharide composition (mainly glucose and mannose with variable ratios), glycosidic linkages, and higher-order self-assembled structures (e.g., triple-helix conformation) dictate its functionality in biological systems and food matrices; (2) chemical modification strategies-including carboxymethylation, graft copolymerization, cross-linking, polysaccharide-trace element complexation, phosphorylation, acetylation, and cholesterylation-that overcome intrinsic limitations of native BSP to enhance solubility, targeting, bioactivity, and food-related functional properties; and (3) the expanding applications of BSP and its derivatives in biomedicine (hemostatic materials, tissue engineering scaffolds, drug delivery systems, immunomodulation, and antitumor effects) and in the food industry (as natural stabilizers, emulsifiers, functional additives, and bio-based packaging components). Compared with previously published reviews, this work establishes a complete closed-loop logical system from structural characterization to rational modification and cross-field application and provides the most up-to-date systematic summary of BSP research. Key challenges-such as an incomplete understanding of structure-function correlations, insufficient pharmacokinetic data, and a lack of standardized quality control-are discussed, and future research directions are proposed. This review aims to provide a systematic theoretical basis for advancing BSP as a versatile multifunctional material for applications in functional foods, nutraceuticals, and biomedical fields.

Abstract licence: CC BY

Abstract Background Anemia is one of the main complications of chronic kidney disease especially kidney failure, which includes treatment with erythropoiesis-stimulating agents and iron supplementation, including intravenous and oral iron. However, intravenous iron may pose limitations, such as potential infusion reactions. Oral iron is mainly composed of divalent iron, which can excessively stimulate the gastrointestinal tract. Iron polysaccharide complex capsules are a novel oral iron trivalent supplement with higher iron content and lower gastrointestinal irritation. However, since high-quality evidence-based medicinal support is lacking, it is necessary to conduct clinical studies to further evaluate the effectiveness and safety of oral iron polysaccharide complex in chronic kidney disease patients. Methods This randomized controlled trial uses an open-label, parallel group design, where the efficacy and safety of maintenance hemodialysis (MHD) participants is evaluated. The experimental group is assigned erythropoietins and iron polysaccharide complex (two capsules each time, bid), and the control group is assigned erythropoietin and sucrose iron (100mg, 2w) injection. Participants (aged 18–75 years) undergoing maintenance hemodialysis were considered for screening. Inclusion criteria included hemoglobin (Hb) ≥110g/L and 20% and 200μg/L and 10 mg/L, and severe secondary hyperparathyroidism (iPTH ≥ 800 pg/mL). Full inclusion and exclusion criteria are described in the “Methods” section. The primary endpoint is TSAT of the participants at week 12. Secondary endpoints include Hb, SF, hematocrit (Hct), HsCRP, pharmacoeconomic evaluation, drug costs, quality of life, and indicators of oxidative stress. The treatment will last for 24 weeks with a follow-up visit at baseline (within 7 days prior to initial treatment) and weeks 4, 8, 12, 16, 20, and 24 after initial treatment. This clinical research includes 9 hemodialysis centers in mainland China and plans to enroll 186 participants. Discussion It is expected that it will provide strong evidence to reveal the clinical efficacy and safety of oral iron in the treatment of chronic CKD-related anemia in MHD patients through this clinical trial. Trial registration Chinese Clinical Trial Registry ChiCTR2000031166. Registered on March 23, 2020

Abstract licence: CC BY 4.0

Renhua Lu (  lurenhua1977@hotmail.com ) Shanghai Jiao Tong University School of Medicine A liated Renji Hospital https://orcid.org/00000003-3555-505X Xu Zhang Taixing People's hospital Xudong Cai Ningbo Hospital of chinese traditional chinese medicine Xiaoxia Wang Tongren Hospital Shanghai Jiaotong University School of Medicine Hua Li Zhejiang University School of Medicine Sir Run Run Shaw Hospital Li Wang Shandong Qianfoshan Hospital Yijun Zhou Shanghai Jiao Tong University School of Medicine A liated Renji Hospital Jianxiao Shen Shanghai Jiao Tong University School of Medicine A liated Renji Hospital Qian Liu Shanghai Jiao Tong University School of Medicine A liated Renji Hospital Haifen Zhang Shanghai Jiao Tong University School of Medicine A liated Renji Hospital Zhaohui Ni Shanghai Jiao Tong University School of Medicine A liated Renji Hospital

Abstract licence: CC BY 4.0

Iron deficiency anemia can lead to a variety of functional disorders, which is one of the highest incidence of nutrient deficiency diseases. The direct addition of iron to food will not only brings difficulties to the production of products, but also brings damages to human body. In recent years, international studies have shown that polysaccharide iron complex (PIC) not only has a variety of pharmacological activities of polysaccharide itself, but also has the function of supplementing iron, so it is a good iron supplement. With the advantages of good solubility, high iron content, low gastrointestinal irritation and high bioavailability, PIC is an effective iron supplement for iron deficiency anemia and has attracted more and more attention. In this paper, the different preparation methods, structural characterization, biological activities and clinical applications of PIC synthesized by natural polysaccharides from plant were reviewed, in order to provide theoretical basis for the development and application of PIC.

Abstract licence: CC BY 4.0