Policosanol 10mg capsules

This study presents a comprehensive scientometric protocol designed to analyze six principal biorefining routes for Policosanol (Pc) extraction. By integrating experimental parameters, publication metrics, and patent indicators, the research reveals asymmetries and convergences across methods such as saponification, solvent extraction, ultrasonic-assisted techniques, molecular distillation, transesterification, and supercritical CO₂. A cross-meta-analysis of articles, reviews, and patents was conducted using Scopus, Web of Science, Intellectual Property (IP) Business Intelligence modality of Orbit® seekers (version 1.9.8) and SciFinder databases. An innovative set of five scientometric indices was applied to the literature as an analytical method, combined with the Technology Readiness Levels (TRL - NASA) and Maturity Readiness Level (MRL - Embrapa) metrics. Completing the methodology, the structured pyramid protocol enabled advanced mapping of international scientific networks and technology readiness levels. Notably, ultrasonic-assisted extraction and transesterification exhibit strong alignment between academic output and industrial interest, while saponification and solvent extraction show marked dissociation especially within the Ibero-American context. This framework offers a replicable model for assessing innovation dynamics and technological convergence in Pc research, supporting future developments in cardiovascular-relevant bioproducts.

Abstract licence: CC BY-NC 4.0

This Cross-Meta-Analysis, based on PROSPERO Protocol (CRD42023425955), addresses two gaps by conducting a regionalized and simultaneous analysis of articles and patents on the six main Policosanol biorefining routes - a multifunctional antihypercholesterolemic - within the dual context of the burgeoning global bioeconomy and strategies for the prevention and treatment of cardiovascular diseases, the leading cause of death worldwide. Most reviews focus on clinical applications, without comparing extraction methods and evaluating their uncertainties. This study employs extensive databases, and high-end bibliometric tools such as Bibliometrix and Orbit Business Intelligence, while examining 18 Ibero-American countries. The main inferences on efficiencies are the advances of Cuba, Spain, Brazil, Chile, Mexico and Portugal, as well as the need for greater academic-industrial coordination amongst themselves. Covering 16 raw materials, highlighting lacquer wax, sugar cane wax, rice bran wax and Ericerus Pela wax, yield analysis reveals: High (0.511 ≤ yield ≤ 0.700): three methods; Moderate (0.381 ≤ yield ≤ 0.510): four methods; Low (0.251 ≤ yield ≤ 0.380): seven methods. These yields signal clear directions for further research, according to biomes and local costs, being useful as a guide for laboratory research, industrial applications and decision makers.

Abstract licence: CC BY-NC 4.0

This study evaluated the efficacy and safety of 20 mg of Cuban policosanol in blood pressure (BP) and lipid/lipoprotein parameters of healthy Japanese subjects via a placebo-controlled, randomized, and double-blinded human trial. After 12 weeks of consumption, the policosanol group showed significantly lower BP, glycated hemoglobin (HbA1c), and blood urea nitrogen (BUN) levels. The policosanol group also showed lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GTP) levels at week 12 than those at week 0: A decrease of up to 9% (p p p p p = 0.003), respectively, than the placebo group and a difference in the point of time and group interaction (p 1c with enhancement of HDL functionalities.

Abstract licence: CC BY