Lithium succinate 8% / Zinc sulfate 0.05% ointment

Aquatic animals have unique physiological mechanisms to absorb and retain minerals from their diets and water. Research and development in the area of mineral nutrition of farmed fish and crustaceans have been relatively slow and major gaps exist in the knowledge of trace element requirements, physiological functions and bioavailability from feed ingredients. Quantitative dietary requirements have been reported for three macroelements (calcium, phosphorus and magnesium) and six trace minerals (zinc, iron, copper, manganese, iodine and selenium) for selected fish species. Mineral deficiency signs in fish include reduced bone mineralization, anorexia, lens cataracts (zinc), skeletal deformities (phosphorus, magnesium, zinc), fin erosion (copper, zinc), nephrocalcinosis (magnesium deficiency, selenium toxicity), thyroid hyperplasia (iodine), muscular dystrophy (selenium) and hypochromic microcytic anemia (iron). An excessive intake of minerals from either diet or gill uptake causes toxicity and therefore a fine balance between mineral deficiency and toxicity is vital for aquatic organisms to maintain their homeostasis, either through increased absorption or excretion. Release of minerals from uneaten or undigested feed and from urinary excretion can cause eutrophication of natural waters, which requires additional consideration in feed formulation. The current knowledge in mineral nutrition of fish is briefly reviewed.

Abstract licence: CC BY

Green synthesis (GS) is a vital method for producing metal nanoparticles with antimicrobial properties. Unlike traditional methods, green synthesis utilizes natural substances, such as plant extracts, microorganisms, etc., to create nanoparticles. This eco-friendly approach results in non-toxic and biocompatible nanoparticles with superior antimicrobial activity. This paper reviews the prospects of green synthesis of metal nanoparticles of silver (Ag), copper (Cu), gold (Au) and metal oxide nanoparticles of zinc (ZnO), magnesium (MgO), cobalt (Co3O4), and titanium (TiO2) using plant extracts from tissues of leaves, barks, roots, etc., antibacterial mechanisms of metal and metal oxide nanoparticles, and obstacles and factors that need to be considered to overcome the limitations of the green synthesis process. The clean surfaces and minimal chemical residues of these nanoparticles contribute to their effectiveness. Certain metals exhibit enhanced antibacterial properties only in GS methods due to the presence of bioactive compounds from natural reducing agents such as Au and MgO. GS improves TiO2 antibacterial properties under visible light, while it would be impossible without UV activation. These nanoparticles have important antimicrobial properties for treating microbial infections and combating antibiotic resistance against bacteria, fungi, and viruses by disrupting microbial membranes, generating ROS, and interfering with DNA and protein synthesis. Nanoscale size and large surface area make them critical for developing advanced antimicrobial treatments. They are effective antibacterial agents for treating infections, suitable in water purification systems, and fostering innovation by creating green, economically viable antibacterial materials. Therefore, green synthesis of metal and metal oxide nanoparticles for antibacterial agents supports several United Nations Sustainable Development Goals (SDGs), including health improvement, sustainability, and innovation.

Abstract licence: CC BY