Levomenthol sticks
Available from pharmacies, supermarkets, and retail outlets
Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils.
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Levomenthol
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Levomenthol
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Part of the Vicks brand family (generic: Levomenthol)
MHRA licensed products
View all licensed products for Levomenthol on the MHRA register
4Head sticks
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Levomenthol
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin.
Food interactions
None known
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 724 interactions
Proteins and enzymes this drug interacts with in the body
PMID:15306801 PMID:15852009 PMID:16174775 PMID:25559186 PMID:37857704
TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel .
PMID:15306801
In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (By similarity).
May plays a role in prostate cancer cell migration PMID:16174775 PMID:25559186
PMID:17259981 PMID:21195050 PMID:21873995 PMID:23199233 PMID:25389312 PMID:33152265
Has a relatively high Ca(2+) selectivity, with a preference for divalent over monovalent cations (Ca(2+) > Ba(2+) > Mg(2+) > NH4(+) > Li(+) > K(+)), the influx of cation into the cytoplasm leads to membrane depolarization .
PMID:19202543 PMID:21195050
Has a central role in the pain response to endogenous inflammatory mediators, such as bradykinin and to a diverse array of irritants. Activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds, such as allylthiocyanate (AITC) from mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an environmental irritant .
PMID:20547126 PMID:25389312 PMID:27241698 PMID:30878828
Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner .
PMID:17164327 PMID:27241698 PMID:31866091 PMID:32641835
Non-electrophile agonists bind at distinct sites in the transmembrane domain to promote channel activation .
PMID:33152265
Also acts as an ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana .
PMID:25389312
May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds (By similarity)
PMID:12077604 PMID:12077606 PMID:26818531 PMID:37648856 PMID:38691614
It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius .
PMID:12077604 PMID:12077606
Activation exhibits an outward rectification .
PMID:12077604
The channel pore can dilate to provide permeability to larger cations .
PMID:37648856
May associate with TRPV1 and may modulate its activity .
PMID:12077606
Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) PMID:21593771
They are however insensitive to dihydropyridines (DHP)
Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain.
Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions
Enzymes involved in drug metabolism — important for understanding drug interactions
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Levomenthol
Additional database identifiers
Drugs Product Database (DPD)
265
Drugs Product Database (DPD)
418
Drugs Product Database (DPD)
15195
ChemSpider
15803
BindingDB
50318482
PDB
XUQ
Guide to Pharmacology
2430
ZINC
ZINC000001482164
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17961
GenAtlas
TRPM8
GeneCards
TRPM8
GenBank Gene Database
AY090109
GenBank Protein Database
20147036
Guide to Pharmacology
500
UniProt Accession
TRPM8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:497
GenAtlas
TRPA1
GeneCards
TRPA1
GenBank Gene Database
Y10601
GenBank Protein Database
3287188
Guide to Pharmacology
485
UniProt Accession
TRPA1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18084
GenAtlas
TRPV3
GeneCards
TRPV3
GenBank Gene Database
AJ487035
Guide to Pharmacology
509
UniProt Accession
TRPV3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1390
GenAtlas
CACNA1C
GeneCards
CACNA1C
GenBank Gene Database
M92270
Guide to Pharmacology
529
UniProt Accession
CAC1C_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1391
GenAtlas
CACNA1D
GeneCards
CACNA1D
GenBank Gene Database
M76558
GenBank Protein Database
179764
Guide to Pharmacology
530
UniProt Accession
CAC1D_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1393
GenAtlas
CACNA1F
GeneCards
CACNA1F
GenBank Gene Database
AJ006216
GenBank Protein Database
3183953
Guide to Pharmacology
531
UniProt Accession
CAC1F_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1397
GenAtlas
CACNA1S
GeneCards
CACNA1S
GenBank Gene Database
U30707
GenBank Protein Database
1698403
Guide to Pharmacology
528
UniProt Accession
CAC1S_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1401
GenAtlas
CACNB1
GeneCards
CACNB1
GenBank Gene Database
M92303
GenBank Protein Database
179806
UniProt Accession
CACB1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1402
GenAtlas
CACNB2
GeneCards
CACNB2
GenBank Gene Database
S60415
GenBank Protein Database
300417
UniProt Accession
CACB2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1403
GenAtlas
CACNB3
GeneCards
CACNB3
GenBank Gene Database
X76555
GenBank Protein Database
435135
UniProt Accession
CACB3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1404
GenAtlas
CACNB4
GeneCards
CACNB4
GenBank Gene Database
U95020
GenBank Protein Database
2058727
UniProt Accession
CACB4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1388
GenAtlas
CACNA1A
GeneCards
CACNA1A
GenBank Gene Database
AF004884
GenBank Protein Database
2213913
UniProt Accession
CAC1A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8154
GenAtlas
OPRK1
GeneCards
OPRK1
GenBank Gene Database
U11053
GenBank Protein Database
532060
Guide to Pharmacology
318
UniProt Accession
OPRK_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
2 active patents
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: