Iodine crystals
Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Yellow Card
Report side effects (MHRA)
Drug safety updates
MHRA alerts for Iodine
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Iodine
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(11)
Cabozantinib for previously treated advanced differentiated thyroid cancer unsuitable for or refractory to radioactive iodine (TA928)
Thyroid disease: assessment and management (NG145)
Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine (TA535)
Acute kidney injury: prevention, detection and management (NG148)
Leg ulcer infection: antimicrobial prescribing (NG152)
Thyroid cancer: assessment and management (NG230)
Surgical site infections: prevention and treatment (NG125)
Selpercatinib for advanced thyroid cancer with RET alterations after treatment with a targeted cancer drug in people 12 years and over (TA1038)
Oxyzyme and Iodozyme 2-layer hydrogel wound dressings with iodine for treating chronic wounds (MIB11)
Selpercatinib for advanced thyroid cancer with RET alterations untreated with a targeted cancer drug in people 12 years and over (TA1039)
Topical antimicrobial dressings for locally infected leg ulcers: late-stage assessment (HTG751)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 31 · Randomised trials: 1 · 1949–2026
Showing the 50 most relevant studies, sorted by most relevant.
M. Zimmermann, V. Galetti
Thyroid Research, 2015
Ryoko Katagiri, Xiaoyi Yuan, S. Kobayashi, et al.
PLoS ONE, 2017
D. Levie, T. Korevaar, S. Bath, et al.
The Journal of Clinical Endocrinology and Metabolism, 2019
M. Dineva, Harry Fishpool, M. Rayman, et al.
The American journal of clinical nutrition, 2020
S. Bath, J. Verkaik-Kloosterman, M. Sabatier, et al.
Nutrition Reviews, 2022
P. Bigliardi, S. A. L. Alsagoff., Hossam Yehia El-Kafrawi, et al.
International journal of surgery, 2017
Wei-ping Xie, Di Cui, Shuran Zhang, et al.
Materials Horizons, 2019
D. Lin, Yat Li
Advanced Materials, 2022
P. Gignac, N. Kley, J. Clarke, et al.
Journal of Anatomy, 2016
J. Huve, A. Ryzhikov, H. Nouali, et al.
RSC Advances, 2018
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-n…
Food interactions
1 warning
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Proteins and enzymes this drug interacts with in the body
PMID:12488351 PMID:18372236 PMID:18708479 PMID:20797386 PMID:31310151 PMID:32084174 PMID:8806637 PMID:9329364
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate PMID:12488351
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:12488351 PMID:18372236 PMID:18708479 PMID:20797386 PMID:31310151 PMID:32084174 PMID:8806637 PMID:9329364
Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate PMID:12488351
PMID:10192399 PMID:11932316 PMID:12107249 PMID:16684826 PMID:24051746
Mediates electroneutral chloride-bicarbonate, chloride-iodide and chloride-formate exchange with 1:1 stoichiometry .
PMID:10644529 PMID:15155570 PMID:24051746 PMID:35601831
Mediates electroneutral iodide-bicarbonate exchange (By similarity)
Proteins that carry this drug through the body
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017
PMID:17532758 PMID:32025030
The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen .
PMID:32025030
Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream .
PMID:32025030
One dimer produces 7 thyroid hormone molecules PMID:32025030
ATC D08AG03
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Iodine
Additional database identifiers
Drugs Product Database (DPD)
7218
ChemSpider
785
PDB
I2I
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11040
GeneCards
SLC5A5
UniProt Accession
SC5A5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12015
GenAtlas
TPO
GeneCards
TPO
GenBank Gene Database
J02969
GenBank Protein Database
339867
Guide to Pharmacology
2526
UniProt Accession
PERT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:399
GenAtlas
ALB
GeneCards
ALB
GenBank Gene Database
V00494
GenBank Protein Database
28590
UniProt Accession
ALBU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11764
GeneCards
TG
UniProt Accession
THYG_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11040
GeneCards
SLC5A5
UniProt Accession
SC5A5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8818
GeneCards
SLC26A4
UniProt Accession
S26A4_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite:
- DrugBank 6.02024Recommended citationKnox C., Wilson M., Klinger C.M., et alDrugBank 6.0: the DrugBank Knowledgebase for 2024Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
- DrugBank 5.02018Wishart D.S., Feunang Y.D., Guo A.C., et alDrugBank 5.0: a major update to the DrugBank database for 2018Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
- DrugBank 4.02014Law V., Knox C., Djoumbou Y., et alDrugBank 4.0: shedding new light on drug metabolismNucleic Acids Res. 2014 Jan 142(1):D1091-7
- DrugBank 3.02011Knox C., Law V., Jewison T., et alDrugBank 3.0: a comprehensive resource for 'omics' research on drugsNucleic Acids Res. 2011 Jan39(Database issue):D1035-41
- DrugBank 2.02008Wishart D.S., Knox C., Guo A.C., et alDrugBank: a knowledgebase for drugs, drug actions and drug targets.Nucleic Acids Research2008 Jan36(Database issue):D901-6
- DrugBank 1.02006Wishart D.S., Knox C., Guo A.C., et alDrugBank: a comprehensive resource for in silico drug discovery and exploration.Nucleic Acids Research2006 Jan 134(Database issue):D668-72