Idoxuridine 5% topical solution
An analog of deoxyuridine that inhibits viral DNA synthesis.
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Idoxuridine
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Idoxuridine
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 3 · Randomised trials: 1 · 1964–2025
Showing the 50 most relevant studies, sorted by most relevant.
L. M. T. Collum, A. Benedict-Smith, I B Hillary
British Journal of Ophthalmology, 1980
- Acyclovir
- Clinical Trials as Topic
- Corneal Ulcer
Diane E Balderson, Gengqian Cai, Michael Fries, et al.
BMC Ophthalmology, 2015
- Acyclovir
- Antiviral Agents
- Idoxuridine
Gilbert Smolin, Masao Okumoto, Scott Feiler, et al.
American Journal of Ophthalmology, 1981
- Idoxuridine
- Keratitis, Dendritic
- Liposomes
B. E. Juel‐Jensen, F. O. MacCallum, Alison MacKenzie, et al.
BMJ, 1970
- Blood Cell Count
- Clinical Trials as Topic
- Dimethyl Sulfoxide
David J. Maggs, Heather E. Clarke
American Journal of Veterinary Research, 2004
- Cidofovir
- Acyclovir
- Antiviral Agents
F. O. MacCallum, B. E. Juel‐Jensen
BMJ, 1966
- Clinical Trials as Topic
- Dimethyl Sulfoxide
- Facial Dermatoses
Giuliana Pia Calia, Xinyue Chen, Binyamin Zuckerman, et al.
2023
D. C. Nolan, M. M. Carruthers, A. Lerner
The New England journal of medicine, 1970
Falcon Mg, B. Jones, Williams Hp, et al.
1981
W. O'brien, H. Edelhauser
Investigative ophthalmology & visual science, 1977
- Cornea
- Endothelium
- Epithelium
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Idoxuridine acts as an antiviral agent by inhibiting viral replication by substi…
Food interactions
None known
Human targets
2 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:9575153
Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate .
PMID:22385435
Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT) PMID:22385435
ATC D06BB01
ATC J05AB02
ATC S01AD01
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Idoxuridine
Additional database identifiers
Drugs Product Database (DPD)
8313
ChemSpider
5694
BindingDB
50370388
PDB
ID2
ZINC
ZINC000003834173
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11830
GenAtlas
TK1
GeneCards
TK1
GenBank Gene Database
K02581
GenBank Protein Database
339709
UniProt Accession
KITH_HUMAN
GenBank Gene Database
AF243477
GenBank Protein Database
8100965
UniProt Accession
KITH_HHV1
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
Linked open data from Wikidata (Q409765), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.