Podophyllin paint
Requires a prescription from a doctor or prescriber
Podophyllin is a resin extracted from the roots of <em>Podophyllum peltatum</em> (American mandrake) and <em>Podophyllum emodi</em>, which contains numerous compounds, amongst which is podophyllin (as well as the drug [podophyllotoxin]).
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Yellow Card reports
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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2 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 13 · 1961–2025
Showing the 50 most relevant studies, sorted by most relevant.
N. Ilie, T. Hilton, S. Heintze, et al.
Dental materials : official publication of the Academy of Dental Materials, 2017
B. Pratap, R. Gupta, Bhuvnesh Bhardwaj, et al.
The Japanese Dental Science Review, 2019
M. Blatz, M. Vonderheide, J. Conejo
Journal of Dental Research, 2018
J. Chesterman, A. Jowett, A. Gallacher, et al.
BDJ, 2017
C. Soares, A. Faria-E-Silva, M. P. Rodrigues, et al.
Brazilian oral research, 2017
Quanyi Liu, Donghui Wang, Zekun Li, et al.
Materials, 2020
Yang Gao, P. Romero, Hongliang Zhang, et al.
Construction and Building Materials, 2019
N. Saba, M. Jawaid, O. Alothman, et al.
Journal of Reinforced Plastics and Composites, 2016
Xiao-Feng Liu, Yan Xiao, Xi Luo, et al.
Chemical Engineering Journal, 2022
Vincent S. D. Voet, T. Strating, Geraldine H. M. Schnelting, et al.
ACS Omega, 2018
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Podophyllin is a cytotoxic agent that has been used topically in the treatment of genital warts.
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
2-24 hr
Dermal…
Half-life
Protein binding
Volume of distribution
Metabolism
Elimination
Clearance
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
2. LD50 (IP) Rat: 15 mg/kg
3.
LD50 (SC) Rat: 8 mg/kg
4. LD50 (IM) Rat: 3 mg/kg
5. LD50 (IP) Mouse: 30 mg/kg
6.
LD50 (SC) Mouse: 24.6 mg/kg
While podophyllin, the herbal extract from which podophyllotoxin is derived, can cause enteritis and potentially fatal CNS depression, podophyllotoxin has been shown to be safe, with minimal toxicity even in large doses. Application can be immediately followed by burning or itching. Small sores, itching and peeling skin can also follow.
How the body processes this drug — absorption, distribution, metabolism, and elimination
Dermal absorption: systemic poisoning was reported after topical application in some cases. Symptoms were delayed between 2-24 hr.
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Podophyllin
Matched from: Podophyllum resin
DrugBank citations
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q421193), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication.