Framycetin 0.5% eye ointment

Background: Wound healing at the split-thickness skin graft (STSG) donor site is an important aspect of reconstructive surgery that has been characterized by pain, delayed healing, and complications. Improving patient outcomes is the ultimate goal, and it is critical and possible to do all that is needed to optimize donor site management. Objectives: Experimental objectives to determine the effectiveness of Betamethasone + Polymyxin B dressing to that of sterile tulle dressing soaked in 1% framycetin sulfate in enhancing donor site healing and minimizing complications. Materials and Methods: A prospective randomized controlled trial was carried out for 12 months at CMH Rawalpindi, Pakistan in the duration from 1st November 2023 to 30th November 2024. Out of 100 patients, both groups were formed, and the donor sites were treated with the dressing. Recovery period, reported pain, and adverse outcomes were assessed at 2-week, 4-week, and 6-week intervals. Results: The beta-methadone and polymyxin B dressing was found to have reduced the length of healing time (12 ± 2.5) as compared to framycetin sulfate dressing (16 ± 3.2) p<0.05 for pain scores and infection rates. Other post-operative-related complications that were lowered included scarring and hyper granulation. Conclusion: Betamethasone + Polymyxin B dressing is more effective in managing the donor site of STSG, has lesser healing time, and less pain and complications.

Abstract licence: CC BY 4.0

Background Hydrogels loaded with antibiotics can be an effective drug delivery systemfor treating skin diseases or conditions such asinburns and wound healing. Objectives The current research work was planned to preparea hydrogel dressing for an effective wound healing. The hydrogel formulation was aimed to provide sustained drug release, reducing the frequency of repeated applying the transdermal drug formulation or patch. Methods Different polymers, polyvinyl alcohol, sodium alginate, and polyvinyl pyrrolidonein varying ratios were used to prepare hydrogels by freeze-thawing method. The prepared hydrogel formulations were loaded with framycetinsulphate (FC-S), a topical aminoglycoside. Results Swelling behaviour, drug release pattern, wereinvestigated.Equilibrium and dynamic studies were conducted at pH 7.4. The prepared hydrogel formulations showed Euilibriumswellingratio of 197.5%. The in-vitro release pattern of FC-Shydrogels was determined by dissolution testing. The prepared hydrogels were characterized by scanning electron microscopy (SEM)andfourier transform infrared (FTIR)spectroscopy.Animal study was conducted on rats to evaluatethe in-vivo therapeutic effectiveness of FC-S hydrogels in wound healing. For that purpose,wounds were induced in the animals. The drug loaded hydrogel dressing was effiecent in wound heaing as the wound treated with FC-S loaded hydrogel was almost completely healed (97%) on the fifth day in comparison to commercially available product (Sofra Tulle gauze) that healed 86%, whereas free FC-S manifested healing at 76%. Conclusion It was observed that hydrogel dressing loaded with FC-S was therapeutically more efficient and can be used as a potential candidate for wound healing.

Abstract licence: CC BY 4.0

Background: Wound dehiscence is wound edges separation due to disrupted wound healing. Wound dehiscence is a complication in 8% of dermatologic surgeries. In this case, secondary infection of the wound occurred, 1% framycetin sulphate tulle was then chosen to interfere microbial protein synthesis, combined with ozonated oil as adjuvant therapy. Ozone oxidizes bacterial phospholipids and lipoproteins, promotes local tissue metabolism, stimulates fibroblast proliferation, facilitates collagen fiber formation, and supports angiogenesis. This case report described a post-excisional biopsy dehisced wound that was treated with 1% framycetin sulphate tulle and ozonated oil, and this case is the first to report a successful management of post-excisional biopsy dehisced wound with ozonated oil as adjuvant. Case Presentation: An 11-year-old female was brought with a purulent wound on her head post-excisional biopsy. Examination of the parietal region showed a solitary ulcer, 1 cm in diameter, irregular edge, granulated tissue base, serous exudate, crusting, edema, and pus. Treatment was 0.9% NaCl compress, 1% framycetin sulphate tulle, and ozonated oil once weekly. Evaluation on day 21 showed ulcer size reduction and on day 28, ulcer turned into a scar, treatment was continued with mometasone 0.1% cream. Day 86 showed secondary cicatricial alopecia. Complications of a wound in hair-bearing area can occur, in this case, secondary cicatricial alopecia.Conclusion: This paper highlights the utilization of ozonated oil as an adjuvant therapy for a favorable outcome in wound healing.

Abstract licence: CC BY-SA 4.0

Palatoplasty is a surgical procedure performed to restore palatal continuity and improve velopharyngeal function in patients with cleft palate. However, postoperative wound healing may influence scar formation, tissue quality, and maxillary growth. Various topical dressings have been used to reduce bacterial colonization and enhance tissue healing. Trigona sp. honey possesses antimicrobial, antioxidant, and anti-inflammatory properties that may promote wound healing, while framycetin sulfate is a commonly used aminoglycoside antibiotic dressing in palatoplasty. In addition, the buccal fat pad technique may improve tissue vascularization and epithelialization. This pilot randomized clinical study aims to evaluate salivary α-amylase levels as a non-invasive biomarker of wound healing in post-palatoplasty patients receiving Trigona sp. honey or framycetin sulfate dressings, with or without buccal fat pad application. Salivary α-amylase levels will be measured preoperatively and on the fourth and seventh days postoperatively to assess inflammatory responses and healing dynamics following surgery. Conditions: Buccal Fat Pad, Cleft Palate, Honey, Salivary Alpha Amylase. Interventions: Trigona sp honey with the buccal fat pad technique, framicetyn sulfate dressing with the buccal fat pad technique, Trigona sp. honey dressing without the buccal fat pad technique, framicetyn sulfate dressing without the buccal fat pad technique.

Source: ClinicalTrials.gov (public domain)