Framycetin 0.5% eye drops

Background: Wound healing at the split-thickness skin graft (STSG) donor site is an important aspect of reconstructive surgery that has been characterized by pain, delayed healing, and complications. Improving patient outcomes is the ultimate goal, and it is critical and possible to do all that is needed to optimize donor site management. Objectives: Experimental objectives to determine the effectiveness of Betamethasone + Polymyxin B dressing to that of sterile tulle dressing soaked in 1% framycetin sulfate in enhancing donor site healing and minimizing complications. Materials and Methods: A prospective randomized controlled trial was carried out for 12 months at CMH Rawalpindi, Pakistan in the duration from 1st November 2023 to 30th November 2024. Out of 100 patients, both groups were formed, and the donor sites were treated with the dressing. Recovery period, reported pain, and adverse outcomes were assessed at 2-week, 4-week, and 6-week intervals. Results: The beta-methadone and polymyxin B dressing was found to have reduced the length of healing time (12 ± 2.5) as compared to framycetin sulfate dressing (16 ± 3.2) p<0.05 for pain scores and infection rates. Other post-operative-related complications that were lowered included scarring and hyper granulation. Conclusion: Betamethasone + Polymyxin B dressing is more effective in managing the donor site of STSG, has lesser healing time, and less pain and complications.

Abstract licence: CC BY 4.0

Background Hydrogels loaded with antibiotics can be an effective drug delivery systemfor treating skin diseases or conditions such asinburns and wound healing. Objectives The current research work was planned to preparea hydrogel dressing for an effective wound healing. The hydrogel formulation was aimed to provide sustained drug release, reducing the frequency of repeated applying the transdermal drug formulation or patch. Methods Different polymers, polyvinyl alcohol, sodium alginate, and polyvinyl pyrrolidonein varying ratios were used to prepare hydrogels by freeze-thawing method. The prepared hydrogel formulations were loaded with framycetinsulphate (FC-S), a topical aminoglycoside. Results Swelling behaviour, drug release pattern, wereinvestigated.Equilibrium and dynamic studies were conducted at pH 7.4. The prepared hydrogel formulations showed Euilibriumswellingratio of 197.5%. The in-vitro release pattern of FC-Shydrogels was determined by dissolution testing. The prepared hydrogels were characterized by scanning electron microscopy (SEM)andfourier transform infrared (FTIR)spectroscopy.Animal study was conducted on rats to evaluatethe in-vivo therapeutic effectiveness of FC-S hydrogels in wound healing. For that purpose,wounds were induced in the animals. The drug loaded hydrogel dressing was effiecent in wound heaing as the wound treated with FC-S loaded hydrogel was almost completely healed (97%) on the fifth day in comparison to commercially available product (Sofra Tulle gauze) that healed 86%, whereas free FC-S manifested healing at 76%. Conclusion It was observed that hydrogel dressing loaded with FC-S was therapeutically more efficient and can be used as a potential candidate for wound healing.

Abstract licence: CC BY 4.0

The present study evaluates the effectiveness of the ethanolic extract of Nymphaea alba in wound healing and administers phytochemicals using "an excision and incision wound model on Wistar strain albino rats". Plant extracts have a higher phytoconstituent concentration, according to “phytochemical screening”. "Phenolic compounds, alkaloids, carbohydrates, flavonides, glycosides, and tannin" were all detected in the ethanolic extract of Nymphaea alba. "The tensile strength of the healed wounds" was assessed using the incision wound model, and the influence of wound healing was assessed using the excision wound model, which took into consideration the epithelialisation time and the percentage of wound closure. Wistar albino rats' dorsal surfaces were subjected to excision and incision wounds. Four groups of six rats each were randomly selected from among them. Group I served as the control group, receiving no treatment other than a basic ointment. Group II was used with framycetin sulphate cream (Soframycin, Aventis) and was regarded as the standard group. Group III was given EENA 2% (w/w), while Group IV was given EENA 5% (w/w). These were considered test groups. Compared to the usual control group, Nymphaea alba significantly rises the percentage of wound contraction, reduces its duration of epithelialisation, and increases the tensile strength of the skin in all forms. In view of the positive results, it may be feasible to conduct additional research to evaluate the efficacy of various wound models.

Abstract licence: CC BY-SA

In this study antibacterial activity assessment of extraction from the herb Echinacea purpurea, solutions of caffeic and chlorogenic acids (representatives of hydroxycinnamic acids), tea tree, eucalyptus, lavender and sage essential oils, and antimicrobial preparations administered intranasally (sodium sulfacetamide, framycetin sulfate, protargol, neomycin sulfate with polymyxin B sulfate) in relation to one of the causative agents of bacterial infectious rhinitis Staphylococcus aureus was evaluated. Bacteriostatic activity was evaluated by sequential dilution in liquid nutrient medium using an indicator of the metabolic cells activity - triphenyltetrazolium chloride, and bactericidal activity was evaluated by subsequent re-sowing on dense nutrient medium and counting of colony-forming units. Sodium sulfacetamide, extraction from the herb Echinacea purpurea, caffeic and chlorogenic acids do not have the stated effect. Among the essential oils studied tea tree essential oil has the greatest bacteriostatic and bactericidal activity and exceeds protargol in these indicators. A stronger effect was noted for framycetin sulfate and neomycin sulfate with polymyxin B sulfate. According to the study results tea tree, eucalyptus, lavender and sage essential oils can be recommended for the composition inclusion in nasal preparations as a more “gentle” replacement of antibiotics.

Abstract licence: CC BY

Abstract Antibacterial creams come in a wide variety, with varying concentrations, prices, levels of activity, active ingredients, and excipients. Based on their ability to suppress the chosen bacterial strains (S. aureus, E. coli, B. subtilis, P. vulgaris) four different commercial antibacterial creams were evaluated as the most popular ones. There were two types of creams: one with gentamicin sulfate and the other with framycetin sulphate. The combination medicine creams included silver sulfadiazine, miconazole nitrate, neomycin sulfate, and chlorhexidine gluconate. In addition to being commonly utilized due to their antibacterial properties, the chosen bacterial strains are principally responsible for the majority of human illnesses and skin disorders. The study explains the four creams that were utilized, how economical they were, how well they worked against various bacterial strains, and how efficient they were whether applied singly or in combination. It also aids in determining which cream performs the best overall. In the antibacterial experiment, the disk diffusion method was used to use all four of the creams. Out of the four antibacterial creams, the study indicates that gentamicin had the highest efficacy. Among the three drugs that make up cream, gentamicin is the most economical and has the biggest zone of inhibition of all four creams combined. This study improves our knowledge of the best cream while also educating pharma providers regarding the advantages of creams.

Abstract licence: CC BY