Flucytosine 125mg/g / Nystatin 12,500units/g vaginal cream
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(4)Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 8 · Randomised trials: 4 · 2001–2026
Showing the 50 most relevant studies, sorted by most relevant.
T. Cloughesy, K. Petrecca, T. Walbert, et al.
JAMA oncology, 2020
Keyvanfar A, Najafiarab H, Talebian N, et al.
2024
- Candida
- Candidiasis, Oral
- HIV Infections
BackgroundOral candidiasis (OC) is a prevalent opportunistic infection in patients with human immunodeficiency virus (HIV) infection. The increasing resistance to antifungal agents in HIV-positive individuals suffering from OC raised concerns. Thus, this study aimed to investigate the prevalence of drug-resistant OC in HIV-positive patients.MethodsPubmed, Web of Science, Scopus, and Embase databases were systematically searched for eligible articles up to November 30, 2023. Studies reporting resistance to antifungal agents in Candida species isolated from HIV-positive patients with OC were included. Baseline characteristics, clinical features, isolated Candida species, and antifungal resistance were independently extracted by two reviewers. The pooled prevalence with a 95% confidence interval (CI) was calculated using the random effect model or fixed effect model.ResultsOut of the 1942 records, 25 studies consisting of 2564 Candida species entered the meta-analysis. The pooled prevalence of resistance to the antifungal agents was as follows: ketoconazole (25.5%, 95% CI: 15.1-35.8%), fluconazole (24.8%, 95% CI: 17.4-32.1%), 5-Flucytosine (22.9%, 95% CI: -13.7-59.6%), itraconazole (20.0%, 95% CI: 10.0-26.0%), voriconazole (20.0%, 95% CI: 1.9-38.0%), miconazole (15.0%, 95% CI: 5.1-26.0%), clotrimazole (13.4%, 95% CI: 2.3-24.5%), nystatin (4.9%, 95% CI: -0.05-10.3%), amphotericin B (2.9%, 95% CI: 0.5-5.3%), and caspofungin (0.1%, 95% CI: -0.3-0.6%). Furthermore, there were high heterogeneities among almost all included studies regarding the resistance to different antifungal agents (I2 > 50.00%, P 2 = 0.00%, P = 0.65).ConclusionsOur research revealed that a significant number of Candida species found in HIV-positive patients with OC were resistant to azoles and 5-fluocytosine. However, most of the isolates were susceptible to nystatin, amphotericin B, and caspofungin. This suggests that initial treatments for OC, such as azoles, may not be effective. In such cases, healthcare providers may need to consider prescribing alternative treatments like polyenes and caspofungin.RegistrationThe study protocol was registered in the International Prospective Register of Systematic Reviews as PROSPERO (Number: CRD42024497963).
Abstract licence: CC BY
X. Lyu, Chen Zhao, Zhimin Yan, et al.
Drug Design, Development and Therapy, 2016
L. S. M. Sigera, D. Denning
Therapeutic Advances in Infectious Disease, 2023
Filipa Sousa, Cecília Nascimento, D. Ferreira, et al.
Advanced drug delivery reviews, 2023
B. Afroozi, Kamyar Zomorodian, F. Lavaee, et al.
Photodiagnosis and photodynamic therapy, 2019
Lily Rundjan, R. Wahyuningsih, Chrissela Anindita Oeswadi, et al.
BMC Pediatrics, 2019
A. Kassem, A. Mohsen, R. Ahmed, et al.
Journal of Molecular Liquids, 2016
A. Rai, S. Misra, S. Panda, et al.
Life, 2022
Elusa Scheibler, Maria Claudia Rosa Garcia, Renata Medina da Silva, et al.
Gerodontology, 2017
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.