Entecavir 50micrograms/ml oral solution sugar free
Requires a prescription from a doctor or prescriber
Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Yellow Card
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Drug safety updates
MHRA alerts for Entecavir
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Entecavir
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Entecavir
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Entecavir on the MHRA register
Baraclude 0.05mg/ml oral solution
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
WHO defined daily dose (DDD)
500 microgram
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(4)
Entecavir for the treatment of chronic hepatitis B (TA153)
Hepatitis B (chronic): diagnosis and management (CG165)
Tenofovir disoproxil for the treatment of chronic hepatitis B (TA173)
Bulevirtide for treating chronic hepatitis D (TA896)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 26 · Randomised trials: 13 · 2006–2026
Showing the 50 most relevant studies, sorted by most relevant.
Cheng‐Hao Tseng, Yao-Chun Hsu, Tzu‐Haw Chen, et al.
The lancet. Gastroenterology & hepatology, 2020
Shravan Dave, Sooyoung Park, M. H. Murad, et al.
Hepatology (Baltimore, Md.), 2020
Lu Cao, Li Li, Lixing Yang, et al.
Frontiers in Pharmacology, 2025
Wu J, Xie S, Ma Y, et al.
2025
- Hepatitis B, Chronic
- Guanine
- Antiviral Agents
Lingbo Hu, Lingbo Hu, Chao Yang, et al.
Frontiers in Pharmacology, 2024
Yong Wang, Jia-yu Wu, Qian Xiang, et al.
Frontiers in Oncology, 2025
Won Choi, Terry Cheuk-Fung Yip, Grace Lai-Hung Wong, et al.
Journal of hepatology, 2022
Mao-bing Chen, Hua Wang, Qi-han Zheng, et al.
PLoS ONE, 2019
K. Cheung, L. Mak, Sze-Hang Liu, et al.
Clinical and Translational Gastroenterology, 2020
J. Hou, Wei Zhao, Chang-Hong Lee, et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2020
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
128-149 hours
Mechanism
By competing with the natural substrate deoxyguanosine triphosphate, entecavir f…
Food interactions
1 warning
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
1.5 hours
Half-life
128-149 hours
Protein binding
13%
Metabolism
Clearance
101.8 mL/min
* renal cl=197.9…
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
Known interactions with other medicines. Always consult a healthcare professional.
Showing 50 of 330 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
* renal cl=197.9 +/- 78.1 mL/min [Mild impaired renal function]
* renal cl=135.6 +/- 31.6 mL/min [Moderate impaired renal function]
* renal cl=40.3 +/- 10.1 mL/min [severe impaired renal function]
* apparent oral cl=588.1 +/- 153.7 mL/min [Unimpaired renal function]
* apparent oral cl=309.2 +/- 62.6 mL/min [Mild impaired renal function]
* apparent oral cl=226.3 +/- 60.1 mL/min [Moderate impaired renal function]
* apparent oral cl=100.6 +/- 29.1 mL/min [severe impaired renal function]
* apparent oral cl=50.6 +/- 16.5 mL/min [severe impaired renal function amnaged with Hemodialysis]
* apparent oral cl=35.7 +/- 19.6 mL/min [severe impaired renal function amnaged with CAPD]
ATC J05AF10
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Entecavir
Additional database identifiers
Drugs Product Database (DPD)
13030
ChemSpider
135679
BindingDB
50248008
ZINC
ZINC000003802690
UniProt Accession
Q3MS49_HBV
DrugBank citations
If you use DrugBank data in your research, please cite:
- DrugBank 6.02024Recommended citationKnox C., Wilson M., Klinger C.M., et alDrugBank 6.0: the DrugBank Knowledgebase for 2024Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
- DrugBank 5.02018Wishart D.S., Feunang Y.D., Guo A.C., et alDrugBank 5.0: a major update to the DrugBank database for 2018Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
- DrugBank 4.02014Law V., Knox C., Djoumbou Y., et alDrugBank 4.0: shedding new light on drug metabolismNucleic Acids Res. 2014 Jan 142(1):D1091-7
- DrugBank 3.02011Knox C., Law V., Jewison T., et alDrugBank 3.0: a comprehensive resource for 'omics' research on drugsNucleic Acids Res. 2011 Jan39(Database issue):D1035-41
- DrugBank 2.02008Wishart D.S., Knox C., Guo A.C., et alDrugBank: a knowledgebase for drugs, drug actions and drug targets.Nucleic Acids Research2008 Jan36(Database issue):D901-6
- DrugBank 1.02006Wishart D.S., Knox C., Guo A.C., et alDrugBank: a comprehensive resource for in silico drug discovery and exploration.Nucleic Acids Research2006 Jan 134(Database issue):D668-72