Didanosine 25mg dispersible chewable tablets sugar free
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen.
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Didanosine
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Didanosine
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Part of the Videx brand family (generic: Didanosine)
MHRA licensed products
View all licensed products for Didanosine on the MHRA register
WHO defined daily dose (DDD)
400 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
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Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Randomised trials: 7 · 1991–2022
Showing the 50 most relevant studies, sorted by most relevant.
J. Montaner, P. Reiss, D. Cooper, et al.
JAMA, 1998
- RNA, Viral
- Zidovudine
- HIV-1
JH Darbyshire
The Lancet, 1996
J. Gerstoft, O. Kirk, N. Obel, et al.
AIDS, 2003
- Abacavir
- Lactates
- Nervous System Diseases
D. Maitland, G. Moyle, J. Hand, et al.
AIDS, 2005
- HIV-1
- Tenofovir
- Adenine
Jean-Michel Molina, G. Chêne, Françoise Ferchal, et al.
The Journal of infectious diseases, 1999
J. Molina, V. Journot, L. Morand‐Joubert, et al.
The Journal of infectious diseases, 2005
J. Molina, A. Marcelin, J. Pavie, et al.
The Journal of infectious diseases, 2005
- Mutation
- RNA, Viral
- HIV-1
James O. Kahn, Stephen W. Lagakos, Douglas D. Richman, et al.
New England Journal of Medicine, 1992
- Acquired Immunodeficiency Syndrome
- AIDS-Related Complex
- Leukocyte Count
R. D’Aquila, M. Hughes, V. Johnson, et al.
Annals of Internal Medicine, 1996
- HIV-1
- Erythema
- Pyridines
I. Sanne, P. Piliero, K. Squires, et al.
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2003
- Atazanavir Sulfate
- HIV
- Lipids
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
30 minutes
Mechanism
Didanosine (ddI) is metabolized intracellularly by a series of cellular enzymes…
Food interactions
2 warnings
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
30-40%
Half-life
30 minutes
Protein binding
5%
Metabolism
Elimination
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 966 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:23438750 PMID:9305964
Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine PMID:9305964
Proteins that transport this drug across cell membranes
PMID:11669456 PMID:11907186 PMID:14675047 PMID:22108572 PMID:23832370 PMID:28534121 PMID:9950961
Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine .
PMID:9887087
Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins .
PMID:28534121
Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion .
PMID:11907186
Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP .
PMID:26377792
Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain .
PMID:22108572 PMID:23832370
May transport glutamate .
PMID:26377792
Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body .
PMID:11669456 PMID:14675047
Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate .
PMID:14675047 PMID:26377792
Xenobiotics include the mycotoxin ochratoxin (OTA) .
PMID:11669456
May also contribute to the transport of organic compounds in testes across the blood-testis-barrier PMID:35307651
PMID:10722669 PMID:10755314 PMID:12527552 PMID:14759222 PMID:15037197 PMID:17379602 PMID:21795683 PMID:26406980 PMID:27995448 PMID:35790189 PMID:8986748
Functions as a Na(+)-independent transporter .
PMID:8986748
Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine .
PMID:10722669 PMID:10755314 PMID:12527552 PMID:14759222 PMID:15037197 PMID:17379602 PMID:26406980 PMID:8986748
Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) .
PMID:21795683 PMID:27995448
Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure PMID:35790189
PMID:10722669 PMID:12527552 PMID:12590919 PMID:16214850 PMID:21795683 PMID:9396714 PMID:9478986
Functions as a Na(+)-independent, passive transporter .
PMID:9478986
Involved in the transport of nucleosides such as inosine, adenosine, uridine, thymidine, cytidine and guanosine .
PMID:10722669 PMID:12527552 PMID:12590919 PMID:16214850 PMID:21795683 PMID:9396714 PMID:9478986
Also able to transport purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) .
PMID:16214850 PMID:21795683
Involved in nucleoside transport at basolateral membrane of kidney cells, allowing liver absorption of nucleoside metabolites .
PMID:12527552
Mediates apical nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier .
PMID:23639800
Mediates both the influx and efflux of hypoxanthine in skeletal muscle microvascular endothelial cells to control the amount of intracellular hypoxanthine available for xanthine oxidase-mediated ROS production (By similarity)
Proteins that carry this drug through the body
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017
ATC J05AF02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Didanosine
Additional database identifiers
Drugs Product Database (DPD)
916
ChemSpider
45864
BindingDB
50404252
PDB
2DI
ZINC
ZINC000013597823
GenBank Gene Database
U28646
GenBank Protein Database
896047
UniProt Accession
Q72547_HV1
GenBank Gene Database
M15654
GenBank Protein Database
326388
UniProt Accession
POL_HV1B1
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7892
GenAtlas
NP
GeneCards
PNP
GenBank Gene Database
X00737
GenBank Protein Database
35565
Guide to Pharmacology
2841
UniProt Accession
PNPH_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:399
GenAtlas
ALB
GeneCards
ALB
GenBank Gene Database
V00494
GenBank Protein Database
28590
UniProt Accession
ALBU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10970
GenAtlas
hROAT1
GeneCards
SLC22A6
GenBank Gene Database
AF057039
GenBank Protein Database
3831566
Guide to Pharmacology
1025
UniProt Accession
S22A6_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11003
GenAtlas
SLC29A1
GeneCards
SLC29A1
GenBank Gene Database
U81375
GenBank Protein Database
1845345
Guide to Pharmacology
1117
UniProt Accession
S29A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11004
GeneCards
SLC29A2
UniProt Accession
S29A2_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q422606), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.