Cocculus indicus 30c homeopathic tablets

BackgroundChemotherapy induced nausea and vomiting (CINV) remains a major problem that seriously impairs the quality of life (QoL) in cancer patients receiving chemotherapy regimens. Complementary medicines, including homeopathy, are used by many patients with cancer, usually alongside with conventional treatment. A randomized, placebo-controlled Phase III study was conducted to evaluate the efficacy of a complex homeopathic medicine, Cocculine, in the control of CINV in non-metastatic breast cancer patients treated by standard chemotherapy regimens.MethodsChemotherapy-naïve patients with non-metastatic breast cancer scheduled to receive 6 cycles of chemotherapy including at least three initial cycles of FAC 50, FEC 100 or TAC were randomized to receive standard anti-emetic treatment plus either a complex homeopathic remedy (Cocculine, registered in France for treatment of nausea and travel sickness) or the matching placebo (NCT00409071 clinicaltrials.gov). The primary endpoint was nausea score measured after the 1st chemotherapy course using the FLIE questionnaire (Functional Living Index for Emesis) with 5-day recall. Secondary endpoints were: vomiting measured by the FLIE score, nausea and vomiting measured by patient self-evaluation (EVA) and investigator recording (NCI-CTC AE V3.0) and treatment compliance.ResultsFrom September 2005 to January 2008, 431 patients were randomized: 214 to Cocculine (C) and 217 to placebo (P). Patient characteristics were well-balanced between the 2 arms. Overall, compliance to study treatments was excellent and similar between the 2 arms. A total of 205 patients (50.9%; 103 patients in the placebo and 102 in the homeopathy arms) had nausea FLIE scores > 6 indicative of no impact of nausea on quality of life during the 1st chemotherapy course. There was no difference between the 2 arms when primary endpoint analysis was performed by chemotherapy stratum; or in the subgroup of patients with susceptibility to nausea and vomiting before inclusion. In addition, nausea, vomiting and global emesis FLIE scores were not statistically different at any time between the two study arms. The frequencies of severe (Grade ≥ 2) nausea and vomiting were low in our study (nausea: P: 17.6% vs C: 15.7%, p=0.62; vomiting: P: 10.8% vs C: 12.0%, p=0.72 during the first course).ConclusionThis double-blinded, placebo-controlled, randomised Phase III study showed that adding a complex homeopathic medicine (Cocculine) to standard anti-emetic prophylaxis does not improve the control of CINV in early breast cancer patients.

Abstract licence: CC BY

Insomnia is a widespread disease that tends to be associated with other problems, like anxiety. The most frequent anxiety disorder is generalized anxiety disorder (GAD), which is characterized by excessive worrying about everyday situations. Medications for insomnia and anxiety can have adverse reactions and the latter may be ineffective in up to 30% of patients. Here we present a case report of a 27-year-old male patient who suffered from persistent insomnia with comorbid GAD and schizophreniform disorder. Initially, he was taking alprazolam, paroxetine, and risperidone, which had a less-than-satisfactory effect. He was treated with individualized homeopathy, which produced a remarkable improvement within four months. This was evidenced by a decrease in difficulty falling asleep and daytime sleepiness; in addition, anxiety and its accompanying symptoms, such as irritability and diaphoresis, were reduced. This improvement persists for up to one year after the commencement of treatment and despite discontinuation of all medications. This clinical report provides preliminary evidence that persistent insomnia and comorbid GAD can be treated successfully with individualized homeopathy. However, further randomized controlled studies are needed to evaluate its efficacy, effectiveness, and safety more conclusively.

Abstract licence: CC BY

Abstract As highlighting the synergetic action of Nanoscale metal along with the biomolecules play crucial role in modern medicine. The silver nanoparticles were owed many uses in the field of medicine; one of the most important approaches of silver nitrate is Anti-urolithiasis effect. The present study focuses on the anti-urolithiasis activity of Cocculus hirsutus leaf extract capped silver nanoparticles (AgNPs). The AgNPs were synthesized by silver nitrate salt solution and Cocculus hirsutus leaf extract in microwave oven. The Microwave assisted synthesis is an efficient technique and promises more environment benign than traditional heating. The newly prepared AgNPs were characterized by various techniques. the invitro struvite crystal preparation and inhibition activity were examined by using freshly prepared silver nanoparticles.

Abstract licence: CC BY 4.0