Coal tar 12% / Salicylic acid 2% in Emulsifying ointment

Psoriasis is an immune-mediated inflammatory skin disease where topical therapy is crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack of targeted delivery to the dermis and epidermis remain challenges. We reviewed the evolution of topical therapies for psoriasis and conducted a bibliometric analysis from 1993 to 2023 using a predictive linear regression model. This included a comprehensive statistical and visual evaluation of each model's validity, literature profiles, citation patterns, and collaborations, assessing R variance and mean squared error (MSE). Furthermore, we detailed the structural features and penetration pathways of emerging drug delivery systems for topical treatment, such as lipid-based, polymer-based, metallic nanocarriers, and nanocrystals, highlighting their advantages. This systematic overview indicates that future research should focus on developing novel drug delivery systems characterized by enhanced stability, biocompatibility, and drug-carrying capacity.

Abstract licence: CC BY-NC

Seborrheic dermatitis (SD) often leads to ocular manifestations (OM) that are frequently overlooked. This study comprehensively explains the genesis of these ocular issues, which involves a combination of Malassezia overgrowth, changes in sebum production, and inflammatory responses in the body. The periocular region is rich in sebaceous glands, allowing Malassezia to thrive, which can lead to an inflammatory reaction that spreads to the eye surface, causing disorders such as blepharitis, conjunctivitis, keratitis, and ocular surface diseases. Although epidemiological data are limited, it is well established that ocular involvement occurs in approximately 10%-40% of individuals with SD. Early detection and treatment are crucial to prevent potential vision-threatening complications. A comprehensive diagnostic approach is necessary, including clinical examination, slit-lamp biomicroscopy, tear film analysis, and corneal imaging. Managing these conditions requires a multidisciplinary strategy involving collaboration between dermatologists and ophthalmologists. The treatment should involve topical and systemic medications to address the skin and ocular components. Patient education is critical for improving adherence to therapy, self-management, and the early identification of problems. In the future, it will be essential to investigate the intricate interactions between Malassezia species and host immunological processes. This collective effort will involve creating new biomarkers and diagnostic tools, investigating targeted immunomodulatory drugs and novel lipid-based medicines as potential treatments, and conducting large-scale longitudinal studies to understand the epidemiological patterns and prognostic variables better. By raising awareness, encouraging collaboration across disciplines, and advancing research, healthcare practitioners can significantly improve patients' quality of life with SD and OM.

Abstract licence: CC BY

Psoriasis is a lingering inflammatory skin disease that attacks the immune system. The abnormal interactions between T cells, immune cells, and inflammatory cytokines causing the epidermal thickening. International guidelines have recommended topical treatments for mild to moderate psoriasis whilst systemic and phototherapy treatments for moderate to severe psoriasis. However, current therapeutic approaches have a wider extent to treat moderate to severe type of psoriasis especially since the emergence of diverse biologic agents. In the meantime, topical delivery of conventional treatments has prompted many unsatisfactory effects to penetrate through the skin (stratum corneum). By understanding the physiology of stratum corneum barrier functions, scientists have developed different types of lipid-based nanoparticles like solid lipid nanoparticles, nanostructured lipid carriers, nanovesicles, and nanoemulsions. These novel drug delivery systems help the poorly solubilised active pharmaceutical ingredient reaches the targeted site seamlessly because of the bioavailability feature of the nanosized molecules. Lipid-based nanoparticles for psoriasis treatments create a paradigm for topical drug delivery due to their lipids' amphiphilic feature to efficiently encapsulate both lipophilic and hydrophilic drugs. This review highlights different types of lipid-based nanoparticles and their recent works of nano formulated psoriasis treatments. The encapsulation of psoriasis drugs through lipid nanocarriers unfold numerous research opportunities in pharmaceutical applications but also draw challenges for the future development of nano drugs.

Abstract licence: CC BY-NC