Ammonia solution dilute
Requires a prescription from a doctor or prescriber
Ammonia is a naturally-occurring compound with a chemical formula NH3 and structure of trigonal pyramidal geometry.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Ammonia
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Ammonia
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(4)
Pegzilarginase for treating arginase-1 deficiency in people 2 years and over (HST35)
Rifaximin for preventing episodes of overt hepatic encephalopathy (TA337)
Cirrhosis in over 16s: assessment and management (NG50)
AmnioSense for unexplained vaginal wetness in pregnancy (MIB198)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Renal excretion and metabolism of ammonia is critical in regulation of acid-base…
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
10-27 minutes
Half-life
3 seconds
[L2033]
Metabolism
Elimination
[L2033]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
- (when radiolabelled) Indicated for diagnostic PET imaging of the myocardium under rest or pharmacologic stress conditions to evaluate myocardial perfusion in patients with suspected or existing coronary artery disease [FDA Label].
While mammals has various mechanisms to detoxify and excrete ammonia from the body, death has been reported after an exposure to 10,000 ppm for an unknown duration. Bradycardia was seen at 2,500 ppm, and hypertension and cardiac arrhythmias leading to cardiovascular collapse followed acute exposures to concentrations exceeding 5,000 ppm .
[L2033]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L2033]
In healthy male subjects under exposure to 500 ppm ammonia for 10-27 minutes, about 70-80% of total inspired ammonia was expired .
[L2033]
In extrahepatic tissues such as the intestine, ammonia is incorporated into nontoxic glutamine and released into blood, where it is transported to the liver for ureagenesis .
[L2033]
[L2033]
[A32385]
In case of hepatic dysfunction or impairment, detoxification capacity decreases and may cause severe pathologies from hyperammonemia, such as hepatic encephalopathy .
[L2033]
[L2033]
Enzymes involved in drug metabolism — important for understanding drug interactions
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Ammonia
Additional database identifiers
Drugs Product Database (DPD)
10102
HUGO Gene Nomenclature Committee (HGNC)
HGNC:29570
GenAtlas
GLS2
GeneCards
GLS2
GenBank Gene Database
AF110330
GenBank Protein Database
6650606
UniProt Accession
GLSL_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4341
GenAtlas
GLUL
GeneCards
GLUL
GenBank Gene Database
Y00387
GenBank Protein Database
31833
UniProt Accession
GLNA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2323
GeneCards
CPS1
UniProt Accession
CPSM_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: