Urea powder
A compound formed in the liver from ammonia produced by the deamination of amino acids.
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Urea
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Urea
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Part of the Eucerin brand family (generic: Urea)
MHRA licensed products
View all licensed products for Urea on the MHRA register
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Urea
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(15)
Intravenous fluid therapy in adults in hospital (CG174)
Hepatitis B (chronic): diagnosis and management (CG165)
Diarrhoea and vomiting caused by gastroenteritis in under 5s: diagnosis and management (CG84)
Acute kidney injury: prevention, detection and management (NG148)
Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management (CG184)
Bipolar disorder: assessment and management (CG185)
Routine preoperative tests for elective surgery (NG45)
The NGAL Test for early diagnosis of acute kidney injury (MIB3)
Suspected sepsis in under 16s: recognition, diagnosis and early management (NG254)
Intravenous fluid therapy in children and young people in hospital (NG29)
Suspected sepsis in pregnant or recently pregnant people: recognition, diagnosis and early management (NG255)
Alcohol-use disorders: diagnosis, assessment and management of harmful drinking (high-risk drinking) and alcohol dependence (CG115)
Metastatic malignant disease of unknown primary origin in adults: diagnosis and management (CG104)
Diverticular disease: diagnosis and management (NG147)
Intrapartum care for women with existing medical conditions or obstetric complications and their babies (NG121)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Not available
Food interactions
None known
Human targets
3 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
[L41484]
Proteins and enzymes this drug interacts with in the body
PMID:11327835 PMID:11802772 PMID:11831900 PMID:12056894 PMID:12171926 PMID:1336460 PMID:14736236 PMID:15300855 PMID:15453828 PMID:15667203 PMID:15865431 PMID:16106378 PMID:16214338 PMID:16290146 PMID:16686544 PMID:16759856 PMID:16807956 PMID:17127057 PMID:17251017 PMID:17314045 PMID:17330962 PMID:17346964 PMID:17540563 PMID:17588751 PMID:17705204 PMID:18024029 PMID:18162396 PMID:18266323 PMID:18374572 PMID:18481843 PMID:18618712 PMID:18640037 PMID:18942852 PMID:1909891 PMID:1910042 PMID:19170619 PMID:19186056 PMID:19206230 PMID:19520834 PMID:19778001 PMID:7761440 PMID:7901850 PMID:8218160 PMID:8262987 PMID:8399159 PMID:8451242 PMID:8485129 PMID:8639494 PMID:9265618 PMID:9398308
Can also hydrate cyanamide to urea .
PMID:10550681 PMID:11015219
Stimulates the chloride-bicarbonate exchange activity of SLC26A6 .
PMID:15990874
Essential for bone resorption and osteoclast differentiation .
PMID:15300855
Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption
PMID:17524503 PMID:18077326 PMID:18086858 PMID:18957423 PMID:21262353 PMID:22155184 PMID:22647378 PMID:22699938
In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome .
PMID:17524503 PMID:18077326 PMID:18086858 PMID:18957423 PMID:21262353 PMID:22155184 PMID:22647378 PMID:22699938
In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes .
PMID:17524503 PMID:18077326 PMID:18086858 PMID:18957423 PMID:21262353 PMID:22155184 PMID:22647378 PMID:22699938
Also acts as a coactivator for other transcription factors, such as NR5A2 .
PMID:22187462
Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes .
PMID:29910125
Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion .
PMID:18086858
Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization .
PMID:21262353
Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2 .
PMID:18957423
Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML .
PMID:22155184
Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity).
Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity)
Proteins that transport this drug across cell membranes
PMID:10514515 PMID:7797558 PMID:7989337 PMID:8997401
Also mediates the transport of urea across the cell membrane of the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity)
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
ATC D02AE01
ATC B05BC02
ATC D02AE51
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Urea
Additional database identifiers
Drugs Product Database (DPD)
8755
ChemSpider
1143
BindingDB
24961
PDB
URE
ZINC
ZINC000008214514
UniProt Accession
DYR_CHICK
HUGO Gene Nomenclature Committee (HGNC)
HGNC:663
GenAtlas
ARG1
GeneCards
ARG1
GenBank Gene Database
M14502
GenBank Protein Database
178995
Guide to Pharmacology
1244
UniProt Accession
ARGI1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1373
GenAtlas
CA2
GeneCards
CA2
GenBank Gene Database
M77181
GenBank Protein Database
179780
Guide to Pharmacology
3092
UniProt Accession
CAH2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2514
GenAtlas
CTNNB1
GeneCards
CTNNB1
GenBank Gene Database
X87838
GenBank Protein Database
860988
UniProt Accession
CTNB1_HUMAN
GenBank Gene Database
AE005174
GenBank Protein Database
12516082
UniProt Accession
MSRP_ECO57
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10919
GeneCards
SLC14A2
UniProt Accession
UT2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10918
GeneCards
SLC14A1
Guide to Pharmacology
982
UniProt Accession
UT1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: