Xylometazoline 70micrograms/dose / Ipratropium bromide 84micrograms/dose nasal spray
Available from a pharmacy with pharmacist advice
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The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
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1 branded products available
Part of the Otrivine brand family (generic: Xylometazoline + Ipratropium)
MHRA licensed products
View all licensed products for Xylometazoline + Ipratropium on the MHRA register
Otrivine Extra Dual Relief 0.5mg/ml / 0.6mg/ml nasal spray
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
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Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
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SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 12 · Randomised trials: 12 · 1981–2026
Showing the 50 most relevant studies, sorted by most relevant.
Hongzhen Xu, L. Tong, P. Gao, et al.
PLoS ONE, 2020
M. H. Dawood, S. Feroz, Sheza Sohail, et al.
Ear, nose, & throat journal, 2024
Seyed Taghi Hashemi, Babak Alikiaii, Niloofar Mohkamkar
Advanced Biomedical Research, 2023
Background: The aim of the present study was to evaluate the effect of ipratropium bromide with violet flower extract, ipratropium bromide with budesonide, and ipratropium bromide alone on the cuff-leak of the endotracheal tube and changes in hemodynamic parameters in intubated patients admitted to the intensive care unit. Materials and Methods: The present randomized clinical trial study was performed on 195 intubated patients in three groups of 65 patients. The first group received nebulized ipratropium bromide with budesonide (I + B group), the second group in addition to ipratropium bromide, received one tablespoon of the violet flower extract syrup every 8 hours (I + V group), and the third group received nebulized ipratropium bromide alone (I group). Hemodynamic parameters and the cuff-leak ratio (CLR) of patients were evaluated up to 72 hours after intubation. Results: The results of the present study revealed that 12 hours after intubation, the mean of CLR was significantly lower in group I (with a mean of 0.14 ± 0.02) as compared with that of the I + V and I + B groups (with the means of 0.16 ± 0.05 and 0.23 ± 0.05, respectively) (P < 0.001). In addition, 24 hours after intubation, the mean of CLR in group I + V was higher than that of I + B and I groups (P < 0.05). Conclusion: According to the results of this study, the use of violet extract syrup in patients under intubation can significantly improve patients' ratio of cuff-leak and SpO2. It seems that the use of violet extract syrup is effective to prevent unwanted complications during intubation and to facilitate patients' breathing.
Abstract licence: CC BY-NC-SA
R. Iramain, J. Castro-Rodriguez, A. Jara, et al.
Pediatric Pulmonology, 2019
R. Bone, M. Boyars, S. Braun, et al.
Chest, 1994
R. Dahl, L. P. Greefhorst, D. Nowak, et al.
American journal of respiratory and critical care medicine, 2001
F. Qureshi, J. Pestian, Paris H. Davis, et al.
The New England journal of medicine, 1998
J. Noord, T. Bantje, M. Eland, et al.
Thorax, 2000
B. O'driscoll, M. Horsley, Robert J. Taylor, et al.
Lancet, 1989
J. V. van Noord, D. D. de Munck, T. Bantje, et al.
The European respiratory journal, 2000
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.