Wheat dextrin 1.1277g tablets

BackgroundDietary fibers can stimulate endogenous glucagon-like peptide-1 (GLP-1) secretion through microbial fermentation and gut hormone signaling, potentially enhancing satiety and supporting weight management. Given the growing interest in non-pharmacological strategies to complement or support tapering of GLP-1 receptor agonist therapy, a structured overview of the human evidence is needed.MethodsA pre-registered scoping review was conducted using PubMed, Scopus and Cochrane Central. Randomized controlled trials in adults assessing circulating GLP-1 concentrations and satiety following supplementation with a single, well-defined dietary fiber were included. Fiber types were categorized based on structural characteristics. Outcomes were summarized qualitatively across fiber categories.ResultsIn total, 1049 papers were screened and 49 publications comprising 52 studies (total n=1,085 participants; median sample size per study=19) were included. Most studies were acute interventions (71%) and conducted in Western populations. Studies reporting increased GLP-1 showed a non-significant tendency to also report increased satiety (OR = 2.95, 95% CI: 0.87-9.98). Dextrins stood out as one of the few fiber categories showing robust effects on both GLP-1 (4 positive studies) and satiety (5 positive studies). Other fibers, such as β-glucans and mannans, showed more uniform effects on satiety or GLP-1, respectively, but did not consistently affect both outcomes simultaneously.ConclusionsAlthough these findings identify dextrins as a promising dietary fiber candidate for future research, the evidence remains constrained by small sample sizes, short interventions, and substantial heterogeneity. Longer-term studies in free-living conditions, including periods of GLP-1 receptor agonist tapering, are needed to capture microbiota adaptation and generate robust real-world evidence.Systematic review registrationhttps://osf.io/cnw4e/overview.

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Global lifespan is rising, alongside increasing age-related conditions. Cognitive disorders such as dementia, are projected to triple in number by 2050. Currently, no cure is available for Alzheimer's disease (AD), the most common form of dementia, and the need for preventative strategies is paramount. Subjective cognitive decline plus (SCD+) lies on the AD continuum, with increased risk of accelerated cognitive decline, providing an ideal target group for early intervention. The microbiota-gut-brain axis (MGBA) is an emerging avenue for prevention, as dietary fibres may beneficially modulate microbiota and microbial metabolites, such as short chain fatty acids and tryptophan-indoles, resulting in improved gastrointestinal and cognitive functioning. PRECODE is a four-armed, randomised, double-blinded, placebo-controlled trial in 164 older adults (60-79 years) with SCD+ and additional "LIfestyle for BRAin Health" (LIBRA) risk factors. The study aims to investigate 26 weeks of supplementation with chicory inulin, resistant dextrin, and seaweed polysaccharide compared to placebo (maltodextrin) on the MGBA. The primary outcome is effects on neurocognition, assessed by brain activation during working memory load measured with blood-oxygen level dependant functional magnetic resonance imaging (BOLD fMRI) and performance during 2-back task. The secondary outcomes include cognition by neuropsychological test battery, brain and intestinal health parameters, and immune and metabolic markers. Findings may guide new preventative modalities in preclinical AD and provide mechanistic insights into the MGBA in individuals at risk for cognitive decline.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT06433037.

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ObjectivePostprandial hyperglycemia is a major risk factor for type 2 diabetes and cardiovascular disease. Inhibition of α-amylase and α-glucosidase can attenuate postprandial glycemic response (PPGR). This study aimed to investigate the inhibitory effects of mulberry leaf and corn silk on these enzymes in vitro and their impact on postprandial glucose (PG) levels in prediabetic individuals using milk-based matrices.Research design and methodsIn vitro, enzyme inhibition was assessed using the DNS method (α-amylase) and pNPG method (α-glucosidase). A randomized crossover trial was conducted in 11 prediabetic individuals with four interventions: pure milk; lactose-hydrolyzed milk; lactose-hydrolyzed milk with mulberry leaf, corn silk, and resistant dextrin; and GOS milk with mulberry leaf and corn silk. PPGR was assessed by area under the glucose curve, 1 and 2 h PG, maximum PG, and 2 h glucose excursion. Paired Wilcoxon signed-rank tests were used for comparisons.ResultsMulberry leaf and corn silk extracts inhibited both enzymes dose-dependently, with synergistic effects. No significant differences in PPGR indices were observed across interventions in the overall prediabetic individuals. However, in the overweight subgroup, the combination of GOS milk supplemented with mulberry leaf and corn silk significantly reduced 1 h PG (median difference [P25, P75]: -0.84 mmol/L [-1.05, -0.49]), maximum PG (-0.54 mmol/L [-0.75, -0.25]), and glucose excursion (-0.62 mmol/L [-0.75, -0.24]) compared to pure milk.ConclusionsMulberry leaf and corn silk extracts inhibit α-amylase and α-glucosidase in vitro and may attenuate postprandial glucose excursions in overweight prediabetic individuals when delivered in a GOS milk matrix.

Abstract licence: CC BY