Vitamin E 400unit / Selenium 100microgram capsules

Background and Objectives: The significance of periodontal disease as a public health issue prompts the exploration of effective treatments, including the potential use of tocopherol (Vitamin E) due to its anti-inflammatory and antioxidant properties. Materials and Methods: The PICO statement (Population, Intervention, Comparator, Outcome) was as follows: In patients with periodontal disease, does tocopherol (Vitamin E) supplementation compared to no supplementation or insufficient Vitamin E intake improve clinical outcomes such as gingival inflammation, pocket depth, and clinical attachment levels? This study searched through PubMed, Scopus, and Web of Science up to June 2024 focused on studies involving human subjects with various forms of periodontal disease, analyzing the impact of tocopherol through dietary or supplementary intake. Primary outcomes evaluated included improvements in gingival inflammation, pocket depth, and clinical attachment levels, with data synthesis conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Quality assessment and risk of bias were meticulously performed for the included observational studies and randomized controlled trials. Results: The meta-analysis incorporated 8 studies that were used for data extraction, totaling 12,832 patients, revealing a heterogeneous response to tocopherol supplementation, with a pooled odds ratio for efficacy in reducing periodontal disease severity at about 0.97 (95% CI: 0.96-0.98). Noteworthy findings indicated a statistically significant increase in clinical attachment loss and pocket depth with odds ratios ranging from 1.15 to 9.33 when Vitamin E was insufficient. However, the considerable heterogeneity (I2 = 88.35%) underscores variations in tocopherol's effectiveness across different populations and study designs. Conclusions: While tocopherol supplementation shows a modest benefit in managing periodontal disease, particularly in reducing clinical attachment levels and pocket depth, the variability in outcomes emphasizes the necessity for more research to establish standardized treatment protocols and dosages.

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Micronutrient deficiencies are not always present in individuals independently and may occur in association with other deficiency processes.ObjectiveVerify the association between the nutritional status of iodine and that of iron, selenium, and zinc in population studies.MethodsA bibliographic search was carried out in Medline, Web of Science, and CINAHL databases, without date and language restrictions, using English search terms and their synonyms. The search terms were joined by the Boolean operator AND while the respective synonyms were connected by OR following the PRISMA guidelines.ResultsA total of 40 articles were included. The studies were published between 1993 and 2025, mostly involving both sexes and the main age groups were children and adolescents. Among the micronutrients analyzed, selenium stood out, being evaluated in 55.0% (n = 22) of the studies, followed by iron in 37.5% (n = 15) and zinc in 27.5% (n = 11). The most commonly used methods for assessing nutritional status were serum selenium, followed by urinary selenium. For iron, hemoglobin, ferritin, and serum iron were used in 73.3% (n = 11), 60.0% (n = 9), and 46.7% (n = 7) of the studies, respectively. For zinc, serum concentration was the most frequently used method; however, in one study, urinary zinc was evaluated. Overall, the nutritional status of iodine was associated with that of selenium, iron, and zinc, although this trend was not observed in some studies.ConclusionsThe coexistence of deficiency processes in an individual still needs to be further elucidated. Combined strategies that effectively combat, prevent, and treat these micronutrient deficiencies must consider the possible interactions between them.

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Micronutrients and nutraceuticals play crucial roles in wound healing and tissue regeneration, supporting various physiological processes. This review aims to synthesize and evaluate the functions of various micronutrients and nutraceuticals, emphasizing the synergistic interactions among different nutrients that facilitate wound healing processes. A thorough literature review was performed using electronic databases, including PubMed, Scopus, Web of Science, Embase, Google Scholar, and Cochrane Library, to identify molecular studies, animal models, randomized controlled trials, and observational human studies published up to January 2000. Two independent reviewers screened the articles, extracted data, and evaluated the Risk of Bias using the Risk of Bias 2 (RoB 2) tool for the 190 studies that met the inclusion criteria. Evidence suggests that bioactive compounds found in functional foods and dietary supplements can help prevent chronic conditions and promote wellness beyond basic nutrition. Vitamins A, C, and E, as well as minerals such as zinc, selenium, and iron, are essential for cell proliferation and the formation of new tissues. Additionally, nutraceuticals, including omega-3 fatty acids, glutamine, arginine, and polyphenols, exhibit anti-inflammatory and antioxidant properties, which promote healing and reduce the risk of infection. Probiotics and other bioactive compounds in nutraceuticals contribute to maintaining the balance of microbiota, reducing inflammation, and stimulating cell regeneration. Significant variability was noted in study design, sample size, intervention dosage, and outcome measures. This evidence underscores the necessity for further well-designed clinical trials to determine the optimal dosages and combinations for specific wound types across diverse patient populations. This systematic review was prospectively registered in PROSPERO (ID: 1072091).

Abstract licence: CC BY