Vitamin E 400unit / Selenium 100microgram capsules

Micronutrients and nutraceuticals play crucial roles in wound healing and tissue regeneration, supporting various physiological processes. This review aims to synthesize and evaluate the functions of various micronutrients and nutraceuticals, emphasizing the synergistic interactions among different nutrients that facilitate wound healing processes. A thorough literature review was performed using electronic databases, including PubMed, Scopus, Web of Science, Embase, Google Scholar, and Cochrane Library, to identify molecular studies, animal models, randomized controlled trials, and observational human studies published up to January 2000. Two independent reviewers screened the articles, extracted data, and evaluated the Risk of Bias using the Risk of Bias 2 (RoB 2) tool for the 190 studies that met the inclusion criteria. Evidence suggests that bioactive compounds found in functional foods and dietary supplements can help prevent chronic conditions and promote wellness beyond basic nutrition. Vitamins A, C, and E, as well as minerals such as zinc, selenium, and iron, are essential for cell proliferation and the formation of new tissues. Additionally, nutraceuticals, including omega-3 fatty acids, glutamine, arginine, and polyphenols, exhibit anti-inflammatory and antioxidant properties, which promote healing and reduce the risk of infection. Probiotics and other bioactive compounds in nutraceuticals contribute to maintaining the balance of microbiota, reducing inflammation, and stimulating cell regeneration. Significant variability was noted in study design, sample size, intervention dosage, and outcome measures. This evidence underscores the necessity for further well-designed clinical trials to determine the optimal dosages and combinations for specific wound types across diverse patient populations. This systematic review was prospectively registered in PROSPERO (ID: 1072091).

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Background and Objectives: The significance of periodontal disease as a public health issue prompts the exploration of effective treatments, including the potential use of tocopherol (Vitamin E) due to its anti-inflammatory and antioxidant properties. Materials and Methods: The PICO statement (Population, Intervention, Comparator, Outcome) was as follows: In patients with periodontal disease, does tocopherol (Vitamin E) supplementation compared to no supplementation or insufficient Vitamin E intake improve clinical outcomes such as gingival inflammation, pocket depth, and clinical attachment levels? This study searched through PubMed, Scopus, and Web of Science up to June 2024 focused on studies involving human subjects with various forms of periodontal disease, analyzing the impact of tocopherol through dietary or supplementary intake. Primary outcomes evaluated included improvements in gingival inflammation, pocket depth, and clinical attachment levels, with data synthesis conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Quality assessment and risk of bias were meticulously performed for the included observational studies and randomized controlled trials. Results: The meta-analysis incorporated 8 studies that were used for data extraction, totaling 12,832 patients, revealing a heterogeneous response to tocopherol supplementation, with a pooled odds ratio for efficacy in reducing periodontal disease severity at about 0.97 (95% CI: 0.96-0.98). Noteworthy findings indicated a statistically significant increase in clinical attachment loss and pocket depth with odds ratios ranging from 1.15 to 9.33 when Vitamin E was insufficient. However, the considerable heterogeneity (I2 = 88.35%) underscores variations in tocopherol's effectiveness across different populations and study designs. Conclusions: While tocopherol supplementation shows a modest benefit in managing periodontal disease, particularly in reducing clinical attachment levels and pocket depth, the variability in outcomes emphasizes the necessity for more research to establish standardized treatment protocols and dosages.

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Cancer survivors experience a range of side effects during and after treatment. There is a need for a rigorous synthesis of the most recent and best available evidence on the role of nutritional supplements for supportive care in cancer, to inform shared decision-making. We searched 5 databases for umbrella reviews, meta-analyses and systematic reviews on nutritional supplements for supportive cancer care, excluding studies on pain, anxiety and depression, which are covered in recent guidelines. We found 52 reviews that reported on 250 RCTs on 18 supplements for 16 indications. Almost all reviews were of low/critically low quality (assessed using A MeaSurement Tool to Assess systematic Reviews version 2). There was moderate-certainty evidence for benefit from the following supplements: amino acids and oral proteolytic enzymes for severity of radiation-induced dermatitis, N-acetyl cysteine for prevention of chemotherapy-induced peripheral neuropathy (CIPN) in individuals with gastrointestinal cancers. There was low to very low certainty evidence that glutamine, zinc, probiotics and melatonin may be effective for oral mucositis; Vitamin E, omega-3 fatty acids, glutamine and other amino acids may be effective for preventing CIPN. Serious adverse events were reported for high-dose Vitamin A, and dose-related adverse events were reported with zinc and Vitamin E. However, the majority of nutritional supplements were associated with only minor adverse events. Due to the low to very low certainty of the majority of evidence, firm clinical recommendations cannot be made. Further research to conclusively evaluate benefit and harm, including potential impact on efficacy of standard treatments, should be conducted.

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Single studies are often cited to support claims of nutritional soundness or unsoundness regarding vegan or meat-based pet foods when compared to nutritional guidelines from authorities such as the Association of American Feed Control Officials (AAFCO), the European Pet Food Industry Federation (FEDIAF), and the National Research Council (NRC). However, there is little overarching evidence concerning the nutritional soundness of these different pet food types. Such overarching evidence is increasingly important as alternative vegan or meat-based pet food types become more available, such as insect-based, raw meat, and microbial protein-based pet foods. In this systematic review, 54 relevant studies examining the nutritional soundness of vegan, vegetarian, or meat-based dog or cat foods were descriptively analyzed. Only 10 (18.5%) studies found no nutritional deficiencies or excesses across their sampled pet foods relative to AAFCO, FEDIAF, or NRC guidelines. Numerous nutrient deficiencies and excesses were found across all pet food types. Most commonly, these included deficiencies in calcium, phosphorus, and zinc for both dog and cat food, as well as the amino acid taurine exclusively in cat food. The nutrients found to be most commonly in excess were also calcium and phosphorus, and copper-with the latter breaching not only FEDIAF requirements, but also EU legislative limits. Meat-based, insect-based, veterinary prescription, and vegan pet food types each had particularly at-risk nutrients that pet food companies should be aware of. For instance, vegan pet foods often performed well in terms of their fatty acid profile and selenium levels, but some had deficiencies in certain B vitamins. In contrast, some meat-based pet foods were prone to selenium deficiencies. Generally speaking, aside from such specific nutritional flaws, problems were observed across all pet food types. In fact, dog and cat foods (including wet and dry, growth and adult maintenance) of various types commonly failed to fulfil multiple nutritional requirements. To safeguard dog and cat health and welfare, urgent interventions are warranted to improve the nutritional soundness of many pet foods.

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BackgroundVitamin E is an antioxidant that plays a crucial function in the reproductive processes of pigs.AimThis study evaluated the reproductive efficacy of ɑ-tocopherol or vitamin E supplementation in pregnant sows.MethodsTwenty-one articles from 1977 to 2021 were included in the database. There were eight parameters observed, such as concentration in the serum during gestation, colostrum concentration, number of piglets per litter at birth, number of stillborn piglets, number of piglets born alive, litter weight at birth, weight of each piglet at birth, and piglet serum concentration on day 1. The data were analyzed using the PROC MIXED procedure in SAS version 9.1.ResultsVitamin E administration in sows led to a statistically significant rise in the level of α-tocopherol in the serum of both sows during gestation and the serum of piglets on the first day after birth. The injection of vitamin E did not yield a statistically significant effect on the observed variables, including an increase in the number of pigs per litter at birth, stillborn piglets, pigs born alive, litter weight at birth, vitamin E levels in colostrum, dan the weight of piglets at delivery.ConclusionsVitamin E supplements are advisable for female pigs to increase the concentration of α-tocopherol in serum throughout pregnancy and enhance α-tocopherol levels in the serum of piglets on the first day after birth.

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Arthropathy was related to macronutrients in an increasing number of studies nowadays. However, the causal effect of macronutrients and micronutrients on them remains unknown. The macronutrient and micronutrient summary statistics from the greatest genome-wide meta-analysis produced by the DietGen and other cohorts and genome-wide association studies statistics of arthropathy from FinnGen were used in this two-sample bidirectional Mendelian randomization investigation. The causal relationship between macronutrients and arthropathy was investigated using inverse variance weighting (IVW), Mendelian randomization (MR)-Egger regression, weighted median, weighted model, and simple mode. IVW estimates suggested that carbohydrates, Iron, Vitamin A, and gamma-tocopherol had casual associations with arthropathy. As for gonarthrosis, the IVW estimate of the carbohydrate (OR: 2.11, 95% CI: 1.20-3.73, PIVW  = 9.70E-3); as for adhesive capsulitis of shoulder, the IVW estimate of Iron (OR: 1.29, 95% CI: 1.16-1.43, PIVW = 2.80E-6); as for rheumatoid arthritis, the IVW estimate of Iron (OR: 1.17, 95% CI: 1.06-1.30, PIVW = 3.00E-3); as for Coxarthrosis, the IVW estimate of Vitamin A (OR: 0.95, 95% CI: 0.94-0.97, PIVW = 2.70E-8); as for adhesive capsulitis of shoulder, the IVW estimate of gamma-tocopherol (OR: 0.36, 95% CI: 0.29-0.44, PIVW = 3.50E-21); in the reserve MR analysis, as for carbohydrate, the IVW estimate of juvenile arthritis (OR: 0.99, 95% CI: 0.99-1.00, PIVW = 4.50E-3); as for protein, the IVW estimate of juvenile arthtitis (OR: 1.01, 95% CI: 1.00-1.01, PIVW = 2.40E-3). As risk factors, this MR investigation discovered that in macronutrients, carbohydrates were causally linked to gonarthrosis and juvenile arthritis. Protein was related to juvenile arthritis. Iron was obviously associated with adhesive capsulitis of the shoulder and rheumatoid arthritis. Vitamin A was related to Coxarthrosis. Gamma-tocopherol related to adhesive capsulitis of the shoulder and gout. To fully understand how they affect arthropathy, more research is required.

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BackgroundChronic obstructive pulmonary disease (COPD) is a progressive, inflammatory airway disorder characterized by a gradual decline in lung function and increased oxidative stress. Both oxidative stress and inflammation are central to its pathophysiology, with trace elements such as zinc, copper, iron, manganese, magnesium, selenium, and calcium playing key roles in various cellular processes.ObjectiveThis article reviews the role of trace elements in COPD, focusing on their involvement in disease pathogenesis and their therapeutic potential. Specifically, we examine the effects of zinc, copper, iron, magnesium, manganese, selenium, and calcium in COPD.MethodsWe performed a comprehensive narrative review of the literature across databases including PubMed, Web of Science, Cochrane Library, and Google Scholar, identifying studies that explore the therapeutic effects of trace elements in COPD. The studies included in the review consisted of cohort analyses, randomized controlled trials, and clinical investigations.ResultsZinc, copper, iron, magnesium, manganese, selenium, and calcium are critical to both the pathophysiology and management of COPD. These trace elements contribute to the regulation of inflammation, the modulation of oxidative stress, and the maintenance of lung function. Zinc and copper, for instance, reduce oxidative stress and modulate immune responses, while iron is essential for oxygen transport. Magnesium, manganese, selenium, and calcium are vital for muscle function, respiratory performance, reducing inflammation, and improving pulmonary function.ConclusionsThe minerals zinc, copper, iron, magnesium, manganese, selenium, and calcium may contribute to beneficial effects as part of the standard therapeutic management of COPD. Maintaining optimal levels of these trace elements may support the regulation of inflammatory processes, a reduction in oxidative stress, and an improvement in the pulmonary function. However, further clinical research is necessary to confirm their efficacy and establish safe dosage recommendations in COPD treatment.

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