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Therapeutically similar medicines
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Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing all 26 studies.
Reviews & meta-analyses: 2 · 2017–2026
Showing all 26 studies, sorted by most relevant.
Toma CC, Marrelli M, Puticiu M, et al.
2024
Arnica L. genus (Asteraceae) comprises perennial herbs native to the temperate and boreal parts of the northern hemisphere. Arnica montana is the main species. It shows different biological activities, such as antioxidant, anti-inflammatory, antibacterial, antifungal, and antitumor effects. The Arnica formulations are mainly used for pain management. This systematic review is aimed at summarizing the studies focusing on the use of Arnica products on pain and inflammatory signs due to traumatic injuries related to sport and surgical interventions as well as to arthritis and other inflammatory conditions. Both phytotherapeutic and homeopathic formulations are taken into account. This paper only includes manuscripts published in mainstream journals. A literature search from Scopus, Web of Science, and PubMed databases has been carried out using a combination of the keywords “Arnica”, “trauma”, “sport”, “injury”, “injuries”, and “pain”. According to the search strategy and inclusion criteria for this study, 42 eligible papers, focusing on both Arnica alone and formulations containing a mixture of plant extracts, have been finally selected. This review critically discusses the in vitro, in vivo, and clinical studies dealing with Arnica products, reporting both positive and negative outcomes, thus providing perspectives for future research on the plant pharmacological potential.
Abstract licence: CC BY
Massara Mzid, S. Ben Khedir, Maryem Ben Salem, et al.
Pharmaceutical Biology, 2017
- Urticaceae
- Anti-Infective Agents
- Antioxidants
CONTEXT: Urtica urens L. (Urticaceae) is an important and commonly used plant for its medicinal and pharmacological properties. OBJECTIVE: We analyzed the antioxidant and antimicrobial activities of the leaves of Urtica urens in ethanol (EtOH) and water (WA) solvents, employing standard analytical methods. MATERIALS AND METHODS: Polyphenol, flavonoid and tannin content of Urtica urens leaves were determined, after their extraction, using EtOH (70%) and WA extracts as well as the antioxidant (DPPH, ABTS, β-carotene and FRAP) and the antibacterial (via the method of dilution tests) activities of EtOH and WA extracts. RESULTS: 245.65 ± 10.2 μg/mL). Ethanol was the most effective with minimum inhibitory concentration (MIC) < 250 μg/mL. WA has no antibacterial activity. DISCUSSION AND CONCLUSION: The results indicate that leaves of Urtica urens could be used as natural antioxidant and antimicrobial agents.
Abstract licence: CC BY
Doukkali Zouhra, Meryem El Jemli, A. Bouyahya, et al.
Progress In Microbes & Molecular Biology, 2023
Important Moroccan medicinal plants known for their food and medicinal potential include Urtica urens and Mercurialis annua. We examined the antioxidant activity of the methanolic and aqueous extracts by several in vitro systems of the assay, namely the ferric reducing/antioxidant power (FRAP) assay, the DPPH radical-scavenging activity, and the ABTS free radical-scavenging capacity. In addition, all active extracts were subjected to phytochemical screening to determine the key groups of chemicals implicated in their therapeutic activity. Total phenolic and flavonoid concentrations were also measured to see how they affected the antioxidant properties of the plant extracts. The extracts of Urtica urens and Mercurialis annua were found to have different levels of antioxidant effect in the systems tested. Based on the three different antioxidant assays, the Mercurialis annua extracts showed the highest values of antioxidant ability, based on the three used assays. Phytochemical testing of studied extracts revealed the presence of flavonoids, anthocyanins, and tannins. Total phenol and flavonoid contents were shown to provide the highest association with different antioxidant methods. The present study provides evidence that the extracts of Urtica urens and Mercurialis annua are a potential source of natural antioxidants, and this justifies their uses in Moroccan traditional medicine.
Abstract licence: CC BY-NC
Ali Khakpour, Negar Ahmadi Shadmehri, Hanif Amrulloh, et al.
Bioactivities, 2023
Various agricultural products are known to have anti-microbial, anti-cancer, and anti-inflammatory effects. As we can mention, Walnut (Juglans regia) husk, orange (Citrus sinensis) peel, Broad bean (Vicia faba) peel, and Nettle (Urtica urens) are proven to have antimicrobial and anticancer actions. Also, plant diseases such a Pectobacterium carotovorum, Ralstonia solanacearum, Dickeya chrysanthemi, and Pseudomonoas syringae are known to cause annual damage to plant products. Therefore, in the current study, the researchers evaluated their antibacterial activity on the mentioned bacteria under in vitro conditions. Extracts of J. regia husk, C. sinensis peel, V. faba outer peel and U. urens were prepared by maceration method and their anti-bacterial activity on P. carotovorum, D. chrysanthemi, P. syringae, R. solancearum was evaluated using blank disk and well diffusion to obtain minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values. J. regia (husk) and V. faba (outer peel) extracts revealed an anti-bacterial effect on all 4 studied bacteria, while C. sinensis (peel) only inhibited the growth of P. syringae and U. urens only had this effect on P. syringae and R. Solancearum. The inhibition zones varied from 8 to 14 mm, while almost all MIC and MBC rates were 6.25 and 12.5 mg/mL, respectively. Based on the antimicrobial results, the extracts that showed suitable antibacterial effects on certain bacteria can be further studied to be used as natural pesticides.
Abstract licence: CC BY
José Teixeira, Pedro Nunes, D. Outor-Monteiro, et al.
Animals : an Open Access Journal from MDPI, 2023
With the aim of improving animal health and productivity, plants or plant extracts that have antimicrobial, antifungal and antioxidant properties are often used in studies with broilers. The aim of this work was to investigate the effect of Urtica urens in broilers. Ninety male Ross chicks were used, randomly placed in 30 pens (three broilers per pen). The broilers were assigned to three treatment groups: group CT (control) received a basal diet; group UU1 received a basal diet with 1% dried Urtica urens; and group UU2 received a basal diet with 2% dried Urtica urens. Each treatment consisted of two feeds, distributed from day 1 to 15 (starter) and from day 15 to 36 (grower). As a result of this study, broilers in the UU1 treatment group had higher weight on day 15 (p = 0.029) and day 36 (p = 0.014) than those in treatments CT and UU2 and a higher daily weight gain between days 1 and 15 (p = 0.028) and days 1 and 36 (p = 0.014). Broilers in the UU1 and UU2 groups had lower serum HDL cholesterol (88.8 and 88.9 mg/dL, respectively) than the CT (96.1 mg/dL). In conclusion, the use of dried Urtica urens at 1% as an additive in broiler diets may affect growth performance and blood HDL cholesterol.
Abstract licence: CC BY
I. Ugulu, M. C. Unver, Y. Doğan
Euro-Mediterranean Journal for Environmental Integration, 2019
Ahmed M. Abd‐ElGawad, Mohamed A. Amin, M. Ismail, et al.
BioResources, 2025
Maarten J. M. Christenhusz, A. Twyford
Wellcome Open Research, 2024
<ns3:p> We present a genome assembly from a specimen of small nettle, <ns3:italic>Urtica urens</ns3:italic> (Streptophyta; Magnoliopsida; Rosales; Urticaceae). The genome sequence has a total length of 339.60 megabases. Most of the assembly is scaffolded into 12 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 335.02 kilobases and 147.51 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 18,378 protein-coding genes. </ns3:p>
Abstract licence: CC BY
Massara Mzid, Khansa Chaabouni, Fatma Ayedi, et al.
Natural product research, 2025
- Imidazoles
- Kidney
- Nitro Compounds
injection provided a significant protection thanks to antioxidant properties.
Abstract licence: CC BY
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.