Urokinase 25,000unit powder for solution for injection vials
Requires a prescription from a doctor or prescriber
Stable angina, acute coronary syndromes, and fibrinolysis
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Urokinase
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Urokinase
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Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
MHRA licensed products
View all licensed products for Urokinase on the MHRA register
Syner-KINASE 25,000unit powder for solution for injection vials
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Urokinase
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
152 found
Half-life
6.2 minutes
Mechanism
Urokinase is a serine protease.
Food interactions
1 warning
Human targets
9 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Half-life
6.2 minutes
[L12138]
Protein binding
Volume of distribution
11.5L
[L12138]
Metabolism
Elimination
[L12138]
Clearance
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Urokinase was granted FDA approval on 16 January 1978.[L12138]
[L12141]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 704 interactions
[L12141]
Treat patients with symptomatic and supportive measures which may include application of local pressure, administration of whole blood or plasma, and administration of aminocaproic acid.
[L12141]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L12138]
[L12138]
[L12138]
Proteins and enzymes this drug interacts with in the body
PMID:6447255
Cleavage of fibronectin and laminin leads to cell detachment and apoptosis.
Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells
PMID:15677461
Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form
PMID:15853774
Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots .
PMID:17912461 PMID:8481516 PMID:9207454 PMID:21925150
As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading .
PMID:9175705
Acts as a regulator of cell migration, independently of its role as protease inhibitor .
PMID:15001579 PMID:9168821
It is required for stimulation of keratinocyte migration during cutaneous injury repair .
PMID:18386027
It is involved in cellular and replicative senescence .
PMID:16862142
Plays a role in alveolar type 2 cells senescence in the lung (By similarity).
Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis PMID:25808697 PMID:27046084
Enzymes involved in drug metabolism — important for understanding drug interactions
Involved compounds
ATC B01AD04
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Urokinase
Additional database identifiers
Drugs Product Database (DPD)
2012
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9071
GenAtlas
PLG
GeneCards
PLG
GenBank Gene Database
X05199
GenBank Protein Database
387026
Guide to Pharmacology
2394
UniProt Accession
PLMN_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9053
GenAtlas
PLAUR
GeneCards
PLAUR
GenBank Gene Database
X51675
GenBank Protein Database
37605
UniProt Accession
UPAR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8583
GenAtlas
SERPINE1
GeneCards
SERPINE1
GenBank Gene Database
X04429
GenBank Protein Database
35272
UniProt Accession
PAI1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8584
GenAtlas
SERPINB2
GeneCards
SERPINB2
GenBank Gene Database
J02685
GenBank Protein Database
189545
UniProt Accession
PAI2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:9052
GenAtlas
PLAU
GeneCards
PLAU
GenBank Gene Database
X02419
GenBank Protein Database
1834524
Guide to Pharmacology
2393
UniProt Accession
UROK_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8723
GenAtlas
SERPINA5
GeneCards
SERPINA5
GenBank Gene Database
J02639
GenBank Protein Database
180550
UniProt Accession
IPSP_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6694
GenAtlas
LRP2
GeneCards
LRP2
GenBank Gene Database
U33837
GenBank Protein Database
1809240
UniProt Accession
LRP2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11344
GenAtlas
ST14
GeneCards
ST14
GenBank Gene Database
AF118224
GenBank Protein Database
6647302
Guide to Pharmacology
2418
UniProt Accession
ST14_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7821
GenAtlas
NID1
GeneCards
NID1
GenBank Gene Database
M30269
GenBank Protein Database
189209
UniProt Accession
NID1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7158
GenAtlas
MMP12
GeneCards
MMP12
GenBank Gene Database
L23808
GenBank Protein Database
435970
Guide to Pharmacology
1636
UniProt Accession
MMP12_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: