Tryptophan 50mg capsules
Requires a prescription from a doctor or prescriber
An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Tryptophan
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Tryptophan
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Tryptophan
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
65 found
Half-life
Not available
Mechanism
A number of important side reactions occur during the catabolism of tryptophan on the pathway to acetoacetate.
Food interactions
None known
Human targets
3 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 703 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:17671174
Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses .
PMID:25691885
Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells .
PMID:25691885
Acts as a suppressor of anti-tumor immunity .
PMID:14502282 PMID:23103127 PMID:25157255 PMID:25691885
Limits the growth of intracellular pathogens by depriving tryptophan .
PMID:25691885
Protects the fetus from maternal immune rejection PMID:25691885
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:16887882 PMID:18337592 PMID:20628049 PMID:23550058 PMID:26426690 PMID:27805744 PMID:31436139
Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (Probable) PMID:28526555
PMID:11827462 PMID:18337592 PMID:28754537
Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels .
PMID:18337592
Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) .
PMID:11827462 PMID:28754537
Plays an important role in homeostasis of aromatic amino acids (By similarity)
Involved compounds
ATC N06AX02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Tryptophan
Additional database identifiers
Drugs Product Database (DPD)
10238
ChemSpider
6066
BindingDB
21974
PDB
TRP
Guide to Pharmacology
717
ZINC
ZINC000000083315
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6059
GenAtlas
INDO
GeneCards
IDO1
GenBank Gene Database
M34455
GenBank Protein Database
306956
Guide to Pharmacology
2829
UniProt Accession
I23O1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12729
GenAtlas
WARS
GeneCards
WARS1
GenBank Gene Database
M77804
GenBank Protein Database
184657
UniProt Accession
SYWC_HUMAN
GenBank Gene Database
M14742
GenBank Protein Database
143784
UniProt Accession
SYW_GEOSE
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12730
GenAtlas
WARS2
GeneCards
WARS2
GenBank Gene Database
AJ242739
GenBank Protein Database
6572289
UniProt Accession
SYWM_HUMAN
GenBank Gene Database
M14742
GenBank Protein Database
143784
UniProt Accession
SYW_GEOSE
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12730
GenAtlas
WARS2
GeneCards
WARS2
GenBank Gene Database
AJ242739
GenBank Protein Database
6572289
UniProt Accession
SYWM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12008
GenAtlas
TPH1
GeneCards
TPH1
GenBank Gene Database
X52836
GenBank Protein Database
37955
Guide to Pharmacology
1241
UniProt Accession
TPH1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:20692
GenAtlas
TPH2
GeneCards
TPH2
GenBank Gene Database
AY098914
GenBank Protein Database
27497159
Guide to Pharmacology
1242
UniProt Accession
TPH2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12729
GenAtlas
WARS
GeneCards
WARS1
GenBank Gene Database
M77804
GenBank Protein Database
184657
UniProt Accession
SYWC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6059
GenAtlas
INDO
GeneCards
IDO1
GenBank Gene Database
M34455
GenBank Protein Database
306956
Guide to Pharmacology
2829
UniProt Accession
I23O1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11708
GeneCards
TDO2
GenBank Gene Database
U32989
GenBank Protein Database
993046
Guide to Pharmacology
2887
UniProt Accession
T23O_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2719
GenAtlas
DDC
GeneCards
DDC
GenBank Gene Database
M76180
GenBank Protein Database
181521
UniProt Accession
DDC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10923
GenAtlas
SLC16A2
GeneCards
SLC16A2
GenBank Gene Database
U05321
GenBank Protein Database
458255
UniProt Accession
MOT8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:17027
GeneCards
SLC16A10
GenBank Gene Database
AB057445
GenBank Protein Database
18640047
UniProt Accession
MOT10_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
1 active patent
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: