Tranexamic acid 350mg/5ml oral solution

Tranexamic acid is an antifibrinolytic that competitively inhibits the activation of plasminogen to plasmin.[L31858] At much higher concentrations it behaves as a noncompetitive inhibitor of plasmin similar to [aminocaproic acid], a similar antifibrinolytic which is 10-fold less potent.[L31883] Tranexamic acid binds more strongly than aminocaproic acid to both the strong and weak receptor sites of the plasminogen molecule in a ratio corresponding to the difference in potency between the compounds. In patients with hereditary angioedema, inhibition of the formation and activity of plasmin by tranexamic acid may prevent attacks of angioedema by decreasing plasmin-induced activation of the first complement protein (C1).[A230113]

Off-target antagonism of GABA(A) receptors may be associated with the development of convulsions and hyperexcitability following tranexamic acid administration[A229383] - the risk appears higher with improper administration or administration during cardiovascular surgery.[L31883] Consider EEG monitoring of patients with a history of seizure.