Tiratricol 350microgram tablets
Requires a prescription from a doctor or prescriber
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Tiratricol
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Clinical guidelines and formulary information
British National Formulary
Tiratricol
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
48 hours
Mechanism
Monocarboxylate transporter 8 (MCT8) is involved in the transport of triiodothyronine (T3) and thyroxine (T4).
Food interactions
3 warnings
Human targets
3 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
0.5 hours
Half-life
48 hours
Protein binding
99%
[L53383]
Metabolism
Elimination
[L53383]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
[L53383]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 519 interactions
[L53383]
Studies suggest enhanced hepatic and skeletal thyromimetic actions by tiratricol.[A274053][A274058] Symptoms of hyperthyroidism have been documented in case reports with the use of dietary supplement tiratricol.[A274043][A274048] Tiratricol was reported to mediate some antiviral [A274063] and antibacterial activities,[A274068] though these effects warrant further investigations.
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L53383]
The bioavailability of tiratricol was 67 ± 6% suggesting tiratricol is well absorbed from the gastrointestinal tract.
[L53383]
[L53383]
[L53383]
[L53383]
Specific metabolic reactions and metabolites of tiratricol have not been characterized.
[L53383]
Proteins and enzymes this drug interacts with in the body
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:14660639 PMID:24867799 PMID:34060352 PMID:8132774
It is strictly dependent on the extracellular presence of sodium .
PMID:14660639 PMID:24867799 PMID:34060352 PMID:8132774
It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate .
PMID:14660639 PMID:34060352
Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation PMID:33222321
ATC H03AA04
ATC D11AX08
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Tiratricol
Additional database identifiers
ChemSpider
5598
BindingDB
18862
PDB
4HY
Guide to Pharmacology
2637
ZINC
ZINC000004217580
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11799
GenAtlas
THRB
GeneCards
THRB
GenBank Gene Database
X04707
GenBank Protein Database
31207
Guide to Pharmacology
589
UniProt Accession
THB_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11796
GenAtlas
THRA
GeneCards
THRA
GenBank Gene Database
X55074
GenBank Protein Database
825639
Guide to Pharmacology
588
UniProt Accession
THA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2867
GenAtlas
DHODH
GeneCards
DHODH
GenBank Gene Database
M94065
GenBank Protein Database
555594
Guide to Pharmacology
2604
UniProt Accession
PYRD_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10905
GeneCards
SLC10A1
GenBank Gene Database
L21893
GenBank Protein Database
410214
Guide to Pharmacology
959
UniProt Accession
NTCP_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: