Ticarcillin 3g / Clavulanic acid 200mg powder for solution for infusion vials

BackgroundInfections caused by Stenotrophomonas maltophilia (S. maltophilia) are particularly difficult to treat because of their intrinsic resistance to multiple antibiotics.ObjectiveThe main aim of this systematic review was to evaluate the prevalence of infections caused by this bacterium across different provinces of Iran. Additionally, the study assessed the resistance rates of commonly prescribed antibiotics to address existing gaps in therapeutic knowledge.MethodsA systematic literature review was conducted to identify relevant original research articles published in English between 2000 and 2024, using Google Scholar, Medline (via PubMed), Embase, and Web of Science. Following screening, all studies reporting antibiotic resistance in clinical isolates of S. maltophilia from Iran were included and analyzed.ResultsA total of 1415 clinical isolates were collected from 16 regions across Iran. Most isolates showed high susceptibility to ticarcillin/clavulanic acid and minocycline (98.5 % and 98.2 %, respectively). Among the genes associated with biofilm formation and antibiotic resistance, sul1 and spgM were the most prevalent (12.4 % and 39.6 %, respectively).ConclusionGiven the low resistance rates to levofloxacin and minocycline, these antibiotics may be considered as potentially effective options for treating S. maltophilia infections in Iran. Trimethoprim-sulfamethoxazole showed comparatively higher resistance rates, suggesting that its clinical efficacy may be declining. The rising isolation of S. maltophilia from clinical specimens in recent years, compared to the previous decade, is of both epidemiological and clinical concern, highlighting the need for ongoing surveillance and prudent antibiotic use.

Abstract licence: CC BY-NC-ND

Pseudomonas aeruginosa is an opportunistic pathogen with a high capacity to adapt to different factors. The aim of this study is to analyze the pathogenicity in P. aeruginosa strains and their resistance to heavy metals and antibiotics, in agricultural soil of the state of Tamaulipas, Mexico. Susceptibility to 16 antibiotics was tested using the Kirby-Bauer method (CLSI). Eight virulence factors (FV) and six genes associated with heavy metal resistance were detected by PCR. As a result, P. aeruginosa was detected in 55% of the samples. The eight virulence factors were identified in ≥80% of the strains. The strains showed some level of resistance to only three antibiotics: 32.8% to ticarcillin, 40.8% to ticarcillin/clavulanic acid and 2.4% to aztreonam. The most frequent heavy metal resistance genes were arsC (92.8%) and copA (90.4%). However, copB and arsB genes were also identified in a percentage greater than 80%, and the least frequent genes were merA in 14.4% and czcA in 7.2%. Although P. aeruginosa strains showed a high percentage of factor virulence (potential ability to cause infections), their high levels of susceptibility to antibiotics lead to the assumption that infections are easily curable.

Abstract licence: CC BY