Testosterone propionate 100mg/2ml solution for injection ampoules
Requires a prescription from a doctor or prescriber
Testosterone propionate is a slower-releasing anabolic steroid with a short half-life.
Minimal controls; includes benzodiazepines and anabolic steroids
Legal requirements and restrictions
Anabolic steroids and related substances. Possession for personal use is not an offence, but supply is controlled.
Legal requirements
- Prescriptions valid for 28 days
- No controlled drugs register required
- No safe custody requirements
- Import/export restrictions apply
Other medicines in this category
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
2 branded products available
WHO defined daily dose (DDD)
18 mg
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary BNF/ATC mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing all 30 studies.
1959–2025
Showing all 30 studies, sorted by most relevant.
C. H. Phoenix, R. Goy, A. Gerall, et al.
Endocrinology, 1959
- Testosterone Propionate
- Guinea Pigs
- Sexual Behavior
Charles A. Barraclough
Endocrinology, 1961
- Infertility
- Infertility, Female
- Testosterone Propionate
C. Wolf, A. Hotchkiss, J. Ostby, et al.
Toxicological sciences : an official journal of the Society of Toxicology, 2002
- Abnormalities, Drug-Induced
- Animals, Newborn
- Anal Canal
K. Döhler, A. Coquelin, F. Davis, et al.
Brain research, 1984
- Diethylstilbestrol
- Ovulation
- Preoptic Area
C. Malcolmson, Chetna Satra, S. Kantaria, et al.
Journal of pharmaceutical sciences, 1998
- Oils
- Plant Oils
- Polyethylene Glycols
D. Dumesic, D. Abbott, J. Eisner, et al.
Fertility and sterility, 1997
- Estradiol
- Fetus
- Follicle Stimulating Hormone
F. Hh
Journal of Endocrinology, 1971
- Body Weight
- Castration
- Ejaculation
S. Breedlove, Carol D. Jacobson, R. Gorski, et al.
Brain research, 1982
- Estradiol
- Neurons
- Organ Size
H. Morse, N. Horike, M. Rowley, et al.
The Journal of clinical endocrinology and metabolism, 1973
- Leydig Cells
- Luteinizing Hormone
- Spermatogenesis
J. T. Watson, E. Adkins-Regan
Hormones and behavior, 1989
- Brain Mapping
- Copulation
- Coturnix
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
4.5 days
Mechanism
The effects of testosterone in humans and other vertebrates occur by way of two…
Food interactions
None known
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
180-210 ng
Half-life
4.5 days
Protein binding
98%
Volume of distribution
75-120 L/kg
[A31625]
Metabolism
[A31625]…
Elimination
90%
Clearance
2000 ml/min
[L1162]…
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
[L1160]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 1101 interactions
[L1162]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[L1162]
The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.
[A31625]
[A31625]
[A31625]
Testosterone is metabolized to 17-keto steroids through two different pathways. The major active metabolites are estradiol and dihydrotestosterone (DHT).
[L1162]
[L1162]
[L1162]
The reported clearance rate is of approximately 2000 ml/min.
[A31625]
Proteins and enzymes this drug interacts with in the body
PMID:19022849
Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation .
PMID:20812024
Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3
Enzymes involved in drug metabolism — important for understanding drug interactions
Proteins that transport this drug across cell membranes
PMID:2897240 PMID:35970996 PMID:8898203 PMID:9038218 PMID:35507548
Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins .
PMID:8898203
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells PMID:2897240 PMID:35970996 PMID:9038218
Proteins that carry this drug through the body
Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration
PMID:19021548
Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity).
Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity).
Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli .
PMID:6234017
Does not prevent iron uptake by the bacterial siderophore aerobactin PMID:6234017
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Testosterone propionate
Additional database identifiers
Drugs Product Database (DPD)
7488
ChemSpider
5774
BindingDB
50215709
ZINC
ZINC000000490791
HUGO Gene Nomenclature Committee (HGNC)
HGNC:644
GenAtlas
AR
GeneCards
AR
GenBank Gene Database
M20132
GenBank Protein Database
178628
Guide to Pharmacology
628
UniProt Accession
ANDR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2228
GenAtlas
COMT
GeneCards
COMT
GenBank Gene Database
M65212
GenBank Protein Database
180920
Guide to Pharmacology
2472
UniProt Accession
COMT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12530
GeneCards
UGT1A1
GenBank Gene Database
M57899
GenBank Protein Database
184473
Guide to Pharmacology
2990
UniProt Accession
UD11_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11284
GenAtlas
SRD5A1
GeneCards
SRD5A1
GenBank Gene Database
M32313
GenBank Protein Database
177767
UniProt Accession
S5A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11285
GenAtlas
SRD5A2
GeneCards
SRD5A2
GenBank Gene Database
M74047
GenBank Protein Database
338469
Guide to Pharmacology
2633
UniProt Accession
S5A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:25812
GeneCards
SRD5A3
UniProt Accession
SR5A3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2637
GenAtlas
CYP3A4
GeneCards
CYP3A4
GenBank Gene Database
M18907
Guide to Pharmacology
1337
UniProt Accession
CP3A4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10839
GenAtlas
SHBG
GeneCards
SHBG
GenBank Gene Database
X16349
GenBank Protein Database
296673
UniProt Accession
SHBG_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:399
GenAtlas
ALB
GeneCards
ALB
GenBank Gene Database
V00494
GenBank Protein Database
28590
UniProt Accession
ALBU_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:40
GenAtlas
ABCB1
GeneCards
ABCB1
GenBank Gene Database
M14758
GenBank Protein Database
307180
Guide to Pharmacology
768
UniProt Accession
MDR1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q1318776), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.