Stannous fluoride 0.4% dental gel sugar free

In recent years there has been a lot of talk about toothpastes with a particular chemical compound: stannous fluoride (SnF2). Its presence is currently still highly controversial, as the latter could have negative health effects. The different companies that produce toothpastes express its dosage in ppm. The purpose of this systematic literature review is to analyze all randomized clinical trials in the literature over the last 10 years and to draw clear results on the function of stannous fluoride, for this purpose the authors performed a Mann–Whitney U Test. Materials: The first analysis of the literature produced a number greater than 800 results, subsequently applying the inclusion and exclusion criteria, and following a manual analysis of the results, 26 manuscripts have been obtained. Results: From the results analyzed in this review, it could be shown that stannous fluoride does not present important contraindications, if not those commonly reported for fluorine. A meta-analysis on enamel loss has been conducted, it shows that SnF2 products provide better results with a p < 0.05 value. Conclusion: This compound could have significant effects in favor of erosion and recalcification of the enamel, on the biofilm formation, gingival inflammation, and in addition, it could be an important aid in the removal of tooth stains and halitosis.

Abstract licence: CC BY 4.0

ObjectiveTo systematically identify and evaluate clinical trials assessing the caries-preventive efficacy of fluoride-free active ingredients in toothpaste formulations.DataRandomized clinical trials analyzing the caries preventive effect of fluoride-free active ingredients in toothpastes.SourcesA PRISMA-related systematic review of MEDLINE and Embase was conducted. Inclusion criteria were human in vivo clinical trials on toothpastes, fluoride-free interventions, and caries-focused outcomes; exclusion criteria were in vitro or animal studies, non-toothpaste products, fluoride-only products, and non-English publications. The review followed the PICO framework: Population - participants of all ages with primary, mixed, or permanent dentition; Intervention - use of a toothpaste with a non-fluoride active ingredient; Comparison - a fluoride-containing toothpaste as control; Outcome - a measurable oral health effect based on in vivo caries estimation.Study selectionFifteen clinical trials met the inclusion criteria. Eleven used fluoride-free, non-therapeutic abrasive toothpastes as placebo controls. Three trials evaluated the caries-preventing efficacy of fluoride-free hydroxyapatite toothpastes across children, adolescents, and adults; one trial evaluated the caries-preventive efficacy of fluoride-free arginine toothpaste in children.ConclusionCaries prevention relies on reducing sugar intake and thorough daily oral care, with toothpaste, containing evolving combinations of remineralizing agents, antibacterials, and abrasives, playing a central role. With growing global interest in fluoride-free options, this literature review shows that clinically proven fluoride alternatives are already in use.Clinical significanceThis review provides evidence-based guidance for dentists when recommending fluoride-free toothpastes to patients.

Abstract licence: CC BY-NC

Article title and bibliographic informationKonradsson K, Lingström P, Emilson CG, Johannsen G, Ramberg P, Johannsen A. Stabilized stannous fluoride dentifrice in relation to dental caries, dental erosion and dentin hypersensitivity: A systematic review. Am J Dent. 2020;33(2):95-105.Source of fundingInformation not available.Type of study/designSystematic review with meta-analysis of data.

Abstract licence: CC BY-NC-ND

AimTo estimate gingivitis effects of a bioavailable gluconate chelated 0.454% stannous fluoride (SnF2 ) family of dentifrices in adult subjects versus positive (triclosan) and negative (NaF or MFP) controls when used ≤3 months.Materials and methodsA meta-analysis evaluated bioavailable gluconate chelated SnF2 dentifrices versus a negative or positive control for gingival bleeding.ResultsIn 18 randomized controlled trials (RCTs) with 2,890 subjects assessing SnF2 paste versus a negative or positive control, the average number of bleeding sites was reduced by 51% and 31%, respectively. The average change (95% CI) in number of bleeding sites was -16.3 (-27.8, -4.9) versus the negative control and -3.6 (-5.4, -1.8) versus the positive control. Subjects with localized or generalized gingivitis had 3.7 times better odds (95% CI [2.8, 5.0]) of shifting to generally healthy using SnF2 versus a negative control and 2.8 times better odds (95% CI [2.1, 3.9]) of shifting to generally healthy using SnF2 versus a positive control. The individual study risk of bias was deemed to be low in all categories of bias.ConclusionThis meta-analysis demonstrates significant gingivitis benefits of bioavailable SnF2 dentifrices when used ≤3 months versus positive (triclosan) and negative (NaF or MFP) controls.

Abstract licence: CC BY-NC-ND