Sotalol 40mg/5ml oral suspension

Patients experiencing an overdose may present with bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia.[Label] Larger intentional overdoses may present as hypotension, bradycardia, cardiac asystole, prolonged QT interval, torsade de pointes, ventricular tachycardia, and premature ventricular complexes.[Label] Stop administering sotalol and observe the patient until the QT interval returns to normal and the heart rate rises above 50 beats per minute.[Label] Hemodialysis may help lower plasma concentrations of sotalol as it is not bound to plasma proteins.[Label] Bradycardia and cardiac asystole may be treated with [atropine], other anticholinergic drugs, beta adrenergic agonists, or transvenous cardiac pacing.[Label]. Second or third degree heart block may be treated with a transvenous cardiac pacemaker.[Label] Hypotension may be treated with [epinephrine] or [norepinephrine].[Label] Bronchospasm may be treated with [aminophylline] or a beta-2 agonist, possibly at higher than normal doses.[Label] Torsade de pointes may be treated with DC cardioversion, transvenous cardiac pacing, epinephrine, or [magnesium sulfate].[Label]

The oral LD50 for rats is 3450mg/kg, intraperitoneal LD50 for rats is 680mg/kg, oral LD50 for mice is 2600mg/kg, and intraperitoneal LD50 for mice is 670mg/kg.MSDS

Pregnant rabbits given 6 times the maximum recommended human dose showed an increase in fetal death and maternal toxicity, while rats given 18 times the maximum recommended human dose had an increased number of fetal resorptions.[Label] Sotalol is present in human breast milk so patients taking sotalol should not breast feed.[Label]

Sotalol has not been found to be carcinogenic.[Label] No studies have been performed regarding mutagenicity or clastogenicity.[Label] In animal studies, sotalol was not associated with a reduction in fertility aside from smaller litter sizes.[Label]

Further information regarding adverse reactions can be found here.
[L6379]