Sodium valproate 200mg modified-release tablets
Requires a prescription from a doctor or prescriber
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Yellow Card
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Drug safety updates
MHRA alerts for Sodium valproate
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Browse substances A–Z in the European adverse reaction database
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
14 branded products available
Part of the Epilim brand family (generic: Sodium valproate)
MHRA licensed products
View all licensed products for Sodium valproate on the MHRA register
Dyzantil 200mg modified-release tablets
Epilim Chrono 200 tablets
Epilim Chrono 200 tablets
Epilim Chrono 200 tablets
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
WHO defined daily dose (DDD)
1.5 gram
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via the NHS dm+d supplementary mapping files (NHSBSA). Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(11)
Epilepsies in children, young people and adults (NG217)
Bipolar disorder: assessment and management (CG185)
Antenatal and postnatal mental health (QS115)
Antenatal and postnatal mental health: clinical management and service guidance (CG192)
Fenfluramine for treating seizures associated with Dravet syndrome (TA808)
Transcutaneous stimulation of the cervical branch of the vagus nerve for cluster headache and migraine (HTG408)
Cenobamate for treating focal onset seizures in epilepsy (TA753)
Medicines associated with dependence or withdrawal symptoms: safe prescribing and withdrawal management for adults (NG215)
Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome (TA615)
Cannabidiol with clobazam for treating seizures associated with Dravet syndrome (TA614)
Suspected neurological conditions: recognition and referral (NG127)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 12 · Randomised trials: 19 · 1977–2026
Showing the 50 most relevant studies, sorted by most relevant.
M de Silva, B M Macardle, M McGowan, et al.
The Lancet, 1996
- Anticonvulsants
- Carbamazepine
- Epilepsy
Andrew Heller, Paul Chesterman, Robert Elwes, et al.
Journal of Neurology Neurosurgery & Psychiatry, 1995
- Epilepsies, Partial
- Epilepsy, Generalized
- Epilepsy, Tonic-Clonic
Tan S, Ng JS, Tang C, et al.
2024
- Valproic Acid
- Anticonvulsants
- Palliative Care
Askar G, Askar O, Altuhafy M, et al.
2024
Hargreaves F, Crewe J, Daniel S
2025
Adnan Z, Jalal AA, Hameed A, et al.
2026
Dipender Gill, Sheena Derry, Philip J Wiffen, et al.
Cochrane Database of Systematic Reviews, 2011
- Analgesics
- Diabetic Neuropathies
- Fibromyalgia
Detria Rahma Gasti, Aulia Sita Hapsari, Karima Iffani Ulifah
Pediatric Sciences Journal, 2023
S. Nevitt, A. Marson, Jennifer Weston, et al.
The Cochrane database of systematic reviews, 2018
Rob C. Sival, P.M.J. Haffmans, Paul A. F. Jansen, et al.
International Journal of Geriatric Psychiatry, 2002
- Aggression
- Dementia
- Placebos
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Scientific data (pharmacology, interactions, ADME) is not yet available for this medicine. Clinical sections are sourced from the NHS dm+d database.