Sodium hyaluronate 0.05% / Ectoine 2% eye drops preservative free

Background: The efficacy of acupotomy combined with hyaluronic sodium acid in the treatment of knee osteoarthritis (KOA) is unclear. Therefore, this meta-analysis aims to evaluate the efficacy of acupotomy combined with hyaluronic sodium acid compared with hyaluronic sodium acid alone in the treatment of KOA. Methods: Studies from 8 Online databases were searched on KOA treatment using acupotomy combined with sodium hyaluronate until May 2022. The primary outcome indicator was clinical effectiveness, and the secondary outcome indicators included the visual analogue scale scores and Lysholm scores. We calculated the weighted mean difference (WMD) or relative risk for all relevant outcomes. Results: Nine studies were identified, involving 644 cases. The results showed that acupotomy combined with intra-articular sodium hyaluronate injection for KOA was superior to sodium hyaluronate injection alone in terms of clinical effectiveness (relative risk = 1.17, 95% confidence interval [CI]: 1.09–1.25, P < .001) and visual analogue scale (WMD = −2.1, 95% CI: −2.25 to 1.95, P < .001), Lysholm score (WMD = 13.83, 95% CI: 3.47–24.19, P = .009). Conclusion: Acupotomy combined with intra-articular sodium hyaluronate injection for KOA is superior to sodium hyaluronate injection alone. Limited by the number and quality of included studies, this conclusion still needs to be verified by more high-quality Research. INPLASY registration number: INPLASY202350029.

Abstract licence: CC BY-NC 4.0

Abstract BACKGROUND This study evaluates the effect of polyvinylpyrrolidone sodium hyaluronate gel (Gelclair®) on palatal wound healing, pain, and bleeding following free gingival graft surgery (FGG). METHODS Thirty-two patients undergoing FGG were randomly assigned to two groups: the test group received Gelclair® and chlorhexidine mouthwash, while the control group received only chlorhexidine. Patients were called at first, third, seventh, fourteenth and twenty-eighth postoperative days and, Visual Analog Scale (VAS), Wound Healing Index (WHI), hydrogen peroxide (H₂O₂) bubbling scores and bleeding situations were recorded. The Friedman test was used for repeated measures, with the Wilcoxon signed-rank test as post-hoc, and the Mann-Whitney U test for between-group comparisons. RESULTS H₂O₂ test values significantly decreased and WHI values significantly increased over time in both groups (p < 0.050). Test and control groups comparison at time points showed the test group showed significantly lower H₂O₂ test values on days 7, 14, and 28 (p < 0.050) and higher WHI values on days 3, 7, 14, and 28 compared to control group. VAS pain, chewing, and burning scores were also significantly lower in the test group on days 1, 3, 7, and 14 compared to control. While on day 1, the control group had a bleeding rate of 105 times higher than the test group (p < 0.001), no significant differences were observed on days 3 and 7. CONCLUSIONS The findings suggest that Gelclair® promotes wound healing and reduces discomfort and bleeding in the palatal donor area after FGG. Trial registration number: NCT06610331 ; Retrospectively registered on 23/09/2024

Abstract licence: CC BY 4.0