Sodium dihydrogen phosphate 10mmol/10ml solution for infusion ampoules
Requires a prescription from a doctor or prescriber
Sodium phosphate is a saline laxative that is thought to work by increasing fluid in the small intestine.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Yellow Card
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Drug safety updates
MHRA alerts for Sodium dihydrogen phosphate
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 5 · 1946–2026
Showing the 50 most relevant studies, sorted by most relevant.
Frits Zernike
Journal of the Optical Society of America, 1964
R. Parsons, F. Zobel
Journal of Electroanalytical Chemistry, 1965
G. Mestres, M. Ginebra
Acta biomaterialia, 2011
K. D. Weaver, Hye-Jin Kim, Jiazeng Sun, et al.
Green Chemistry, 2010
J. Jerphagnon, S. K. Kurtz
Physical Review B, 1970
W. P. Mason
Physical Review, 1946
Hegde NN, Somanatha H, Lakshmi V C, et al.
2026
Li S, Shi H, Wang Y, et al.
2025
Tsai P, Maalouf NM
2026
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
44 found
Half-life
Not available
Mechanism
Sodium phosphate is thought to work by increasing the amount of solute present i…
Food interactions
None known
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
1-3h
[A19448]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medicines. Always consult a healthcare professional.
Showing 50 of 781 interactions
[L799]
Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma .
[A19449]
Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients .
[A19448]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A19448]
Proteins that transport this drug across cell membranes
PMID:11009570 PMID:16790504 PMID:17494632 PMID:19726692 PMID:7929240 PMID:8041748
May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification .
PMID:11009570
Essential for cell proliferation but this function is independent of its phosphate transporter activity PMID:19726692
PMID:12205090 PMID:15955065 PMID:16790504 PMID:17494632 PMID:22327515 PMID:28722801 PMID:30704756
Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity)
PMID:12324554 PMID:20335586 PMID:26047794 PMID:8327470
The cotransport has a Na(+):Pi stoichiometry of 3:1 and is electrogenic (By similarity)
PMID:11880379
The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity)
ATC A06AG01
ATC V03AG05
ATC A06AD17
ATC B05XA09
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Sodium phosphate, monobasic
Matched from: Sodium dihydrogen phosphate
Additional database identifiers
Drugs Product Database (DPD)
293
Drugs Product Database (DPD)
4753
Drugs Product Database (DPD)
4759
Drugs Product Database (DPD)
20445
ChemSpider
22626
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10946
GeneCards
SLC20A1
UniProt Accession
S20A1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10947
GeneCards
SLC20A2
UniProt Accession
S20A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11019
GeneCards
SLC34A1
UniProt Accession
NPT2A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11020
GeneCards
SLC34A2
Guide to Pharmacology
1136
UniProt Accession
NPT2B_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:20305
GeneCards
SLC34A3
UniProt Accession
NPT2C_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite:
- DrugBank 6.02024Recommended citationKnox C., Wilson M., Klinger C.M., et alDrugBank 6.0: the DrugBank Knowledgebase for 2024Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
- DrugBank 5.02018Wishart D.S., Feunang Y.D., Guo A.C., et alDrugBank 5.0: a major update to the DrugBank database for 2018Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
- DrugBank 4.02014Law V., Knox C., Djoumbou Y., et alDrugBank 4.0: shedding new light on drug metabolismNucleic Acids Res. 2014 Jan 142(1):D1091-7
- DrugBank 3.02011Knox C., Law V., Jewison T., et alDrugBank 3.0: a comprehensive resource for 'omics' research on drugsNucleic Acids Res. 2011 Jan39(Database issue):D1035-41
- DrugBank 2.02008Wishart D.S., Knox C., Guo A.C., et alDrugBank: a knowledgebase for drugs, drug actions and drug targets.Nucleic Acids Research2008 Jan36(Database issue):D901-6
- DrugBank 1.02006Wishart D.S., Knox C., Guo A.C., et alDrugBank: a comprehensive resource for in silico drug discovery and exploration.Nucleic Acids Research2006 Jan 134(Database issue):D668-72