Sodium citrate 4g oral powder sachets
Available from pharmacies, supermarkets, and retail outlets
Sodium citrate is the sodium salt of citric acid.
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Safety monitoring data
Yellow Card reports
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Suspected adverse reactions reported for Sodium citrate
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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Suspected adverse reactions reported for Sodium citrate
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1 branded products available
MHRA licensed products
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Numark cystitis treatment 4g oral powder sachets
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Sodium citrate
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(3)
Constipation in children and young people: diagnosis and management (CG99)
Renal and ureteric stones: assessment and management (NG118)
Urinary tract infection (recurrent): antimicrobial prescribing (NG112)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
156 found
Half-life
18-54 min
Mechanism
Citrate chelates free calcium ions preventing them from forming a complex with t…
Food interactions
1 warning
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
98-130min
[A19414]
Half-life
18-54 min
Volume of distribution
19-39L
[A19414]
Metabolism
[A19419] [L795]
Elimination
[A19414] [A19415]
Clearance
313-1107mL/min
[A19414]
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
practically insoluble in alcohol. Like citric acid, it has a sour taste.
From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
[L788] [L789]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 810 interactions
[L790]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A19414]
[A19414]
[A19419] [L795]
[A19414] [A19415]
[A19414]
Proteins and enzymes this drug interacts with in the body
PMID:15563508 PMID:16686544 PMID:16807956 PMID:17127057 PMID:17314045 PMID:17652713 PMID:17705204 PMID:18618712 PMID:19186056 PMID:19206230 PMID:7625839
May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis .
PMID:15563508
It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid PMID:15563508
Proteins that transport this drug across cell membranes
PMID:11083877
Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate .
PMID:11083877
Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable)
PMID:10894787 PMID:8967342 PMID:9668069
Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic .
PMID:10894787 PMID:8967342 PMID:9668069
Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood .
PMID:10894787
Has a critical role in renal dicarboxylate transport (By similarity)
PMID:12445824 PMID:12826022 PMID:26324167 PMID:26384929 PMID:30054523 PMID:33597751
May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis .
PMID:12826022
Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form .
PMID:12445824 PMID:12826022 PMID:26324167 PMID:26384929 PMID:30054523 PMID:33597751
Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate .
PMID:26324167
The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic .
PMID:12445824 PMID:12826022
Involved in the regulation of citrate levels in the brain (By similarity)
PMID:26870663 PMID:29031613 PMID:29238895 PMID:39881208
Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate .
PMID:29031613
In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes PMID:29031613 PMID:29238895 PMID:39881208
ATC B05CB02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Sodium citrate
Additional database identifiers
Drugs Product Database (DPD)
10290
Drugs Product Database (DPD)
11969
ChemSpider
5989
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1375
GenAtlas
CA4
GeneCards
CA4
GenBank Gene Database
M83670
GenBank Protein Database
179791
Guide to Pharmacology
2599
UniProt Accession
CAH4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:14411
GeneCards
SLC25A21
UniProt Accession
ODC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10917
GenAtlas
SLC13A2
GeneCards
SLC13A2
GenBank Gene Database
U26209
GenBank Protein Database
1098557
UniProt Accession
S13A2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:23089
GeneCards
SLC13A5
Guide to Pharmacology
981
UniProt Accession
S13A5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10979
GeneCards
SLC25A1
Guide to Pharmacology
1051
UniProt Accession
TXTP_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: