Sodium bicarbonate 8.4% (1mmol/ml) solution for injection 50ml pre-filled syringes
Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Sodium bicarbonate
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Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
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1 branded products available
Part of the KliarVax brand family (generic: Sodium bicarbonate)
MHRA licensed products
View all licensed products for Sodium bicarbonate on the MHRA register
Sodium bicarbonate 8.4% solution for injection 50ml Minijet pre-filled syringes
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Sodium bicarbonate
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(6)
Diabetes (type 1 and type 2) in children and young people: diagnosis and management (NG18)
Acute kidney injury: prevention, detection and management (NG148)
DyeVert Systems for reducing the risk of acute kidney injury in coronary and peripheral angiography (HTG594)
i STAT CG4+ and CHEM8+ cartridges for point-of-care testing in the emergency department (MIB38)
Chronic kidney disease: assessment and management (NG203)
The NxStage System One NX1000‑1 home haemodialysis device for renal replacement therapy in chronic kidney disease (MIB12)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Sodium bicarbonate is a systemic alkalizer, which increases plasma bicarbonate,…
Food interactions
1 warning
Human targets
2 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 249 interactions
Proteins and enzymes this drug interacts with in the body
PMID:10200233 PMID:17187064 PMID:21349352 PMID:22457051 PMID:23280837 PMID:23280838 PMID:34997220 PMID:9843794
In cardiomyocytes, may generate the transient outward potassium current I(To) (By similarity). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation .
PMID:10200233 PMID:17187064 PMID:21349352 PMID:22457051 PMID:23280837 PMID:23280838 PMID:34997220 PMID:9843794
Channel properties are modulated by interactions with regulatory subunits .
PMID:17187064 PMID:34997220
Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation .
PMID:17187064 PMID:34997220
Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics PMID:34997220
PMID:27149520 PMID:9670923 PMID:9930755
T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable).
They may also be involved in the modulation of firing patterns of neurons .
PMID:15048902
In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia PMID:25907736 PMID:27729216
Proteins that transport this drug across cell membranes
PMID:10347222 PMID:12403779 PMID:14578046 PMID:14736710
Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis .
PMID:29779931
Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells PMID:35772404
PMID:18577713
Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity)
PMID:18319254
Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange .
PMID:18319254
Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity).
Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity)
ATC B05CB04
ATC B05XA02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Sodium bicarbonate
Additional database identifiers
Drugs Product Database (DPD)
9197
Drugs Product Database (DPD)
11289
Drugs Product Database (DPD)
9735
ChemSpider
8609
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6239
GeneCards
KCND3
GenBank Gene Database
AF048712
GenBank Protein Database
2935434
UniProt Accession
KCND3_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:1395
GenAtlas
CACNA1H
GeneCards
CACNA1H
GenBank Gene Database
AF051946
GenBank Protein Database
14670397
Guide to Pharmacology
536
UniProt Accession
CAC1H_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11030
GeneCards
SLC4A4
UniProt Accession
S4A4_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11033
GeneCards
SLC4A7
UniProt Accession
S4A7_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11034
GeneCards
SLC4A8
UniProt Accession
S4A8_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:18168
GeneCards
SLC4A5
UniProt Accession
S4A5_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:13811
GeneCards
SLC4A10
UniProt Accession
S4A10_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
8 active patents, 11 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
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