Sodium acid phosphate 700mg / Potassium dihydrogen phosphate 305mg tablets

studies suggest comparable or superior sealing ability relative to conventional calcium silicate cements, human clinical evidence is minimal or absent. Degradation and resorption profiles of MPCs may further affect their suitability as scaffolds in regenerative endodontics. Overall, MPCs represent promising investigational materials, yet claims regarding clinical readiness are premature. Careful evaluation of their physicochemical behaviour, biological safety, and practical handling is essential before consideration for routine clinical use.

Abstract licence: CC BY-NC-SA

This study investigates the effects of phosphoric acid (H3PO4), potassium dihydrogen phosphate (KH2PO4) and sodium dihydrogen phosphate (NaH2PO4) admixtures on the setting time, compressive strength and water resistance of magnesium oxychloride cement (MOC). MOC samples incorporating different admixtures are prepared, and their hydration products and microstructures are studied via X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results indicate that the addition of H3PO4, KH2PO4 and NaH2PO4 reduces the initial and final setting times and decreases the compressive strength. However, the compressive strength of MOC is higher than 30.00 MPa with the addition of 2.0 wt.% phosphoric acid and its phosphate after 14 days of air curing. The water resistance of modified MOC slurries is significantly improved. The softening coefficient of MOC with 2.0 wt.% H3PO4 is 1.2 after 14 days of water immersion, which is 3.44 times higher than that of the neat MOC. The enhancement in water resistance is attributed to the formation of amorphous gel facilitated by H3PO4, KH2PO4 and NaH2PO4. Furthermore, the improvement in water resistance is manifested as H3PO4 > KH2PO4 > NaH2PO4.

Abstract licence: CC BY

A UPLC-MS/MS method was developed for simultaneous determination of 7 whitening ingredients: nicotinamide, kojic acid, Tranexamic acid, raspberry glycoside, azelaic acid, magnesium ascorbate phosphate and β-Arbutin in cosmetics. The whitening active components were extracted from cosmetics by supersonic extraction with sodium chloride and dichloromethane to disperse the sample, and supersonic extraction with 0.015 mol/L potassium dihydrogen phosphate solution purified by HLB solid phase extraction column, scanned and detected by electrospray ionization source with positive and negative ion alternate scanning mode and multiple reaction monitoring mode. The results showed that the whitening active ingredients were separated within 3 minutes, with a good linear relationship (R>0.999), and the detection limit was 0.10mg/kg~0.75mg/kg. The recoveries (n=6) were 78.84%-104.85%, and the RSDs were 0.24%-11.35%. This method is suitable for the rapid determination of whitening active ingredients in cosmetics.

Abstract licence: CC BY

The concentration of mitoxantrone in the blood of mice was determined by a high-performance liquid chromatography-ultraviolet method with aloe-emodin as the internal standard. The separation was performed on a Hypersil BDS2 column (4.6 × 250 mm, 5 μm) as the analytical column, the mobile Phase A was acetonitrile, and B was 20-mM potassium dihydrogen phosphate (adding 1% triethylamine and adjusting the pH to 2.8 with phosphoric acid) and 4.6-mM sodium octyl sulfonate. The flow rate was 1.0 mL·min-1, the detection wavelength was 243 nm, the column temperature is 25 ± 5°C and the injection amount was 20 μL. Finally, the linear range of mitoxantrone was 5-200 μg·mL-1, and the correlation coefficient was r = 0.9999. The recovery rate of the method was 91.93-105.5%, and the extraction recovery rate was 91.45-105.5%. The intraday precision and interday precision were <3.29% (limit of detection = 0.3 μg·mL-1). The HPLC method established in this paper was simple, rapid, sensitive and accurate, and can be used to determine the content of mitoxantrone in mouse plasma after tail vein injection.

Abstract licence: Public domain

Dental enamel is susceptible to acid-induced demineralization and while fluoride treatments are effective, they have limitations such as superficial remineralization and risk of fluorosis. This in vitro study examined the remineralization potential of calcium phosphate (CaP) nanoparticles, bioactive glass (BAG) nanoparticles and nano-hydroxyapatite (nHAp) on artificially demineralized human enamel. Energy-dispersive X-ray spectroscopy and Vickers microhardness were used to assess the 60 premolars after they were prepared, separated into four groups (control, CaP, nHAp and BAG), demineralized and treated daily for seven days. All nanoparticle groups showed significant remineralization versus control, with nHAp achieving the highest hardness and Ca/P ratio, followed by BAG and CaP. Thus, we show nHAp as the most effective non-invasive remineralizing agent for early carious lesions.

Abstract licence: CC BY