Silicone topical gel
Silicon is under investigation in clinical trial NCT00103246 (Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides).
Official documents, adverse reaction reporting, and safety monitoring
Report a side effect
Submit a Yellow Card report to the MHRA
Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
View Drug Analysis Profile
Suspected adverse reactions reported for Silicone
Browse all iDAP reports
Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
Search EudraVigilance database
Browse substances A–Z in the European adverse reaction database
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
21 branded products available
Part of the Kelo-cote brand family (generic: Silicone)
MHRA licensed products
View all licensed products for Silicone on the MHRA register
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(14)
Artificial trapeziometacarpal joint replacement for end-stage osteoarthritis (HTG67)
Collagen injection for vocal cord augmentation (HTG79)
Macular translocation with 360° retinotomy for wet age-related macular degeneration (HTG216)
Endoscopic dacryocystorhinostomy (HTG68)
Artificial metacarpophalangeal and interphalangeal joint replacement for end-stage arthritis (HTG66)
Insertion of a collagen plug to close an abdominal wall enterocutaneous fistula (HTG359)
Injectable bulking agents for faecal incontinence (HTG135)
Insertion of an epiretinal prosthesis for retinitis pigmentosa (HTG372)
Extraurethral (non-circumferential) retropubic adjustable compression devices for stress urinary incontinence in women (HTG434)
Artificial iris insertion for congenital aniridia (HTG547)
Intramural urethral bulking procedures for stress urinary incontinence in women (HTG86)
Fluid-filled thermal balloon and microwave endometrial ablation techniques for heavy menstrual bleeding (TA78)
Artificial iris insertion for acquired aniridia (HTG546)
The MIST Therapy system for the promotion of wound healing (HTG267)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing all 30 studies.
Reviews & meta-analyses: 8 · 2017–2023
Showing all 30 studies, sorted by most relevant.
U. Eduok, Omar Faye, J. Szpunar
Progress in Organic Coatings, 2017
P. Mazurek, Sindhu Vudayagiri, A. Skov
Chemical Society reviews, 2019
The tutorial aims to equip the beginners in silicone research with the knowledge to formulate recipes and process elastomer networks, targeting specific properties related to soft applications such as stretchable electronics without compromising the mechanical integrity of the elastomer. In doing so, we hope to stimulate further research in the area of tailor-made soft silicone elastomers for novel applications and allow researchers to bypass the limitations imposed by the use of commercially available silicone elastomer formulations. Silicone elastomers are widely used due to the favourable properties, such as flexibility, durable dielectric insulation, barrier properties against environmental contaminants and stress-absorbing properties over a wide range of temperatures ≈-100 °C to 250 °C. For research on flexible electronics and other emerging technologies, the most commonly utilised silicone elastomer formulation is Sylgard 184 which is easier to process than most other commercially available silicone elastomers, due to the fact that the premixes have low viscosity. Furthermore, curing is robust and not as sensitive to poisoning as other silicone elastomer formulations. However, Sylgard 184 is not suitable for all fields of research that require flexible and stretchable silicones. When much softer networks are needed, the Sylgard 184 premixes are either mixed in non-stoichiometric ratios, or they are blended with softer types of commercially available elastomers, which compromise the mechanical integrity of the elastomer. Therefore, it is advantageous for researchers to formulate their own custom-made silicone elastomers and not depend on premade formulations which often harbour a few unknown components.
Abstract licence: CC BY-NC
M. Zare, Erfan Rezvani Ghomi, P. Venkatraman, et al.
Journal of Applied Polymer Science, 2021
A. Atalay, Vanessa Sanchez, O. Atalay, et al.
Advanced Materials Technologies, 2017
Peng Hu, Qingyi Xie, Chunfeng Ma, et al.
Langmuir : the ACS journal of surfaces and colloids, 2020
Qian Wu, Li‐Xiu Gong, Yang Li, et al.
ACS nano, 2017
C. S. O’Bryan, Tapomoy Bhattacharjee, Samuel M. Hart, et al.
Science Advances, 2017
C. Virden, M. Dobke, P. Stein, et al.
Aesthetic Plastic Surgery, 2020
- Silicones
- Tissue Expansion Devices
- Contracture
Heng Yang, X. Yao, Zhong Zheng, et al.
Composites Science and Technology, 2018
Elham Davoodi, H. Montazerian, R. Haghniaz, et al.
ACS nano, 2020
- Wearable Electronic Devices
- Biological Monitoring
- Cell Survival
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Not available
Food interactions
1 warning
Human targets
None mapped
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Show
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
Show earlier publications
Structured knowledge from the free knowledge base
Molecular structure
Linked open data from Wikidata (Q670), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. Molecular structure images from Wikimedia Commons.