Sennosides 7.5mg tablets

Sennoside A and B, the components of senna, are metabolized by gut bacteria into the active metabolite rheinanthrone DB13175[A19235]. Rheinanthrone DB13175 appears to increase cyclooxegenase 2 (COX2) expression in macrophage cells leading to an increase in prostaglandin E2 (PGE2)[A19235]. This increase in PGE2 is associated with a decrease in aquaporin 3 expression in mucosal epithelial cells of the large intestine[A19235]. A decrease in aquaporin 3 expression likely produces the laxative effect by restricting water reabsorption by the large intestine thereby increasing fecal water content[A19235]. The exact mechanism by which rheinanthrone increases COX2 expression is unknown[A19235]. Rheinanthrone DB13175 also stimulates peristalsis in the large intestine although the mechanism behind this effect is unknown[A19239]. Rhein DB13174, another active metabolite is thought to excite submucosal acetylcholinergic neurons resulting in increased chloride and prostaglandin secretion[A19247][A19258]. The movement of chloride ions into the large intestine would also help to draw water into the lumen[A19258].