Secretin 20microgram powder and solvent for solution for injection ampoules
Requires a prescription from a doctor or prescriber
Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver.
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Secrelux 20microgram powder and solvent for solution for injection ampoules
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(3)
Pancreatitis (NG104)
Autism spectrum disorder in under 19s: support and management (CG170)
Autism spectrum disorder in adults: diagnosis and management (CG142)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
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Supply & safety information
Official UK regulator monitoring and safety alerts
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Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary.
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing all 27 studies.
Reviews & meta-analyses: 5 · 2012–2026
Showing all 27 studies, sorted by most relevant.
Yongguo Li, K. Schnabl, S. Gabler, et al.
Cell, 2018
- Eating
- Thermogenesis
- Adipose Tissue, Brown
Kristoffer L. Egerod, M. S. Engelstoft, Kaare V. Grunddal, et al.
Endocrinology, 2012
- Gene Expression Regulation
- Cell Separation
- Cholecystokinin
J. Swensson, A. Zaheer, D. Conwell, et al.
AJR. American journal of roentgenology, 2020
- Expert Testimony
- Image Enhancement
- Pancreas
S. Afroze, F. Meng, K. Jensen, et al.
Annals of translational medicine, 2013
Zhaofeng Yan, M. Yin, Dandan Xu, et al.
Nature Structural &Molecular Biology, 2017
- Type II Secretion Systems
- Protein Conformation, beta-Strand
- Amino Acid Sequence
T. Tirkes, K. Sandrasegaran, R. Sanyal, et al.
Radiographics : a review publication of the Radiological Society of North America, Inc, 2013
- Secretin
- Bile Duct Diseases
- Contrast Media
R. Manfredi, R. Pozzi Mucelli
Radiology, 2016
- Magnetic Resonance Imaging
- Pancreatic Diseases
- Secretin
Nan Wu, F. Meng, P. Invernizzi, et al.
Hepatology (Baltimore, Md.), 2016
- Receptor, Transforming Growth Factor-beta Type I
- Cell Line
- Fibronectins
W. Chey, T. Chang
Pancreas, 2014
- Dogs
- Pancreas
- Pancreatic Juice
Emily Lorenzen, T. Dodig-Crnković, Ilana B. Kotliar, et al.
Science Advances, 2019
Abstract Although receptor activity-modifying proteins (RAMPs) have been shown to modulate the functions of several different G protein-coupled receptors (GPCRs), potential direct interactions among the three known RAMPs and hundreds of GPCRs has never been investigated. We engineered three epitope-tagged RAMPs and 23 epitope-tagged GPCRs, focusing on the secretin-like family of GPCRs, and developed a suspension bead array (SBA) immunoassay designed to detect RAMP-GPCR complexes. We then used 64 antibodies raised against native RAMPs and GPCRs, along with four antibodies targeting the epitope tags, to multiplex the SBA assay to detect and measure all possible combinations of interaction among the 23 GPCRs and three RAMPs. The results of the SBA assay provide a complete interactome of secretin-like GPCRs with RAMPs. We demonstrate direct interaction of previously reported secretin-like GPCRs whose functions are modulated by RAMPs. We also discovered novel sets of GPCR-RAMP interacting pairs, and found additional secretin-like GPCRs, chemokine receptors and orphan receptors that interact with RAMPs. Using in situ roximity ligation assay, we verified a subset of these novel GPCR-RAMP interactions in cell membranes. In total, we found GPCR-RAMP interactions for the majority of the 23 GPCRs tested. Each GPCR interacted with either all three RAMPs or with RAMP2 and RAMP3, with the exception of one GPCR that interacted with just RAMP3. In summary, we describe an SBA strategy that will be useful to search for GPCR-RAMP interactions in cell lines and tissues, and conclude that GPCR-RAMP interactions are more common than previously appreciated.
Abstract licence: CC BY-NC-ND
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
45 minutes
Mechanism
Synthetic human secretin mediates the same biological effects as the naturally-o…
Food interactions
None known
Human targets
2 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
90 to 120 minutes
Half-life
45 minutes
Volume of distribution
2.7 L
Clearance
51.3 mL/min
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Purified synthetic human secretin, also referred to as RG1068, is available as an intravenous injection under the market name ChiRhoStim ® in the U.S.. It contains an amino acid sequence identical to the naturally occurring hormone consisting of 27 amino acids [FDA Label] that supports α-helical formation [A32275]. The carboxyl-terminal amino acid, valine, is amidated. Synthetic human secretin displays equivalent biological activity and properties as naturally-occurring secretin [A32265]. It is indicated for the stimulation of the pancreatic and gastric secretions to aid in the diagnosis of pancreatic exocrine dysfunction and the diagnosis of gastrinoma, and facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP).
- pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction [FDA Label].
- gastrin secretion to aid in the diagnosis of gastrinoma [FDA Label].
- pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP) [FDA Label].
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 163 interactions
[L1875]
Studies assessing the carcinogenic potential, mutagenicity, or potential for impairment of fertility have not been conducted with synthetic human secretin [FDA Label].
In a baseline-controlled study of patients with acute and acute recurrent pancreatitis undergoing magnetic resonance cholangiopancreatography (MRCP), administration of synthetic human secretin resulted in higher levels of sensitivity with minimal loss in specificity. This indicates that the stimulation of pancreatic secretions by synthetic secretin facilitates the diagnosis and clinical decision making of patients acute, acute recurrent, or chronic pancreatitis [A32267].
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:25332973 PMID:32811827 PMID:33008599 PMID:7612008
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway .
PMID:32811827 PMID:33008599
Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation.
Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity)
PMID:25332973
Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells .
PMID:25332973 PMID:33008599 PMID:32811827
Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (By similarity). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity).
In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (Probable). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity).
Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (By similarity). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity)
ATC V04CK01
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Secretin human
Matched from: Secretin
Additional database identifiers
Drugs Product Database (DPD)
2067
ChemSpider
17314768
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10608
GenAtlas
SCTR
GeneCards
SCTR
GenBank Gene Database
U20178
GenBank Protein Database
662796
Guide to Pharmacology
252
UniProt Accession
SCTR_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10607
GeneCards
SCT
UniProt Accession
SECR_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: