Sargramostim 250micrograms powder for solution for injection vials
Requires a prescription from a doctor or prescriber
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast.
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Sargramostim
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
Clinical guidelines and formulary information
British National Formulary
Sargramostim
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Sargramostim binds to the Granulocyte-macrophage colony stimulating factor recep…
Food interactions
None known
Human targets
4 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Clearance
420 mL/min
* 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
* 549 mL/min/m2 [Normal…
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 9 of 9 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
* 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
* 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
* 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]
Proteins and enzymes this drug interacts with in the body
PMID:10527461
Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)
PMID:1495999
In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway PMID:9516124
ATC L03AA09
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Sargramostim
Additional database identifiers
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2435
GenAtlas
CSF2RA
GeneCards
CSF2RA
GenBank Gene Database
X17648
GenBank Protein Database
32089
Guide to Pharmacology
1707
UniProt Accession
CSF2R_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:6012
GenAtlas
IL3RA
GeneCards
IL3RA
GenBank Gene Database
M74782
GenBank Protein Database
186331
UniProt Accession
IL3RA_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2436
GenAtlas
CSF2RB
GeneCards
CSF2RB
GenBank Gene Database
M59941
GenBank Protein Database
487425
UniProt Accession
IL3RB_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10659
GenAtlas
SDC2
GeneCards
SDC2
GenBank Gene Database
J04621
GenBank Protein Database
386787
UniProt Accession
SDC2_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
Patent information
All patents expired, 1 expired
Source: DrugBank · CC BY-NC 4.0. Patent data sourced from national patent offices. Expiry dates may not reflect extensions, regulatory exclusivity periods, or legal challenges.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: