Salicylic acid 2% / Mucopolysaccharide polysulfate 0.2% gel

Background: Mucopolysaccharide polysulfate (MPS) cream as a moisturizer is widely applied to treat eczema, and a lot of clinical trials have demonstrated its efficacy and safety. However, there is no further research to collect and analyze these studies.Objective: This meta-analysis aimed to assess the efficacy and safety of MPS cream as monotherapy or add-on therapy for non-exudative eczema.Methods: Ten databases were searched to identify the eligible randomized controlled trials (RCTs) from their inception to July 31, 2021. Revman 5.3 software was used for the meta-analysis.Results: A total of eligible 20 studies were included. Among the 20 studies, 2 studies compared MPS cream with other moisturizers, 14 compared MPS cream plus topical corticosteroids (TCS) with TCS alone, and 4 compared with MPS cream plus tacrolimus ointment with tacrolimus ointment alone. The pooled results demonstrated that MPS cream had a higher total efficacy rate [Risk ratio (RR) 1.21, 95% CI: 1.12 to 1.30, P < 0.00001], a lower recurrence rate (RR 0.44, 95% CI: 0.26 to 0.74, P = 0.002) and a lower pruritus score [mean difference (MD) −1.78, 95% CI: −2.16 to −1.40, P < 0.00001] than urea cream or vaseline ointment. Moreover, in comparison with TCS or tacrolimus ointment alone, the combination treatment performed better in terms of total efficacy rate, total symptom score, recurrence rate, and pruritus score. For safety, the skin adverse events were mild, and MPS cream as monotherapy or add-on therapy did not increase the risk of skin adverse events.Conclusions: MPS cream as monotherapy or add-on therapy could provide a good effect for treating non-exudative eczema with mild and tolerable skin adverse events. However, due to the suboptimal quality of the included studies, high-quality and large-sample RCTs are needed in the future for update or validation.Systematic Review Registration: PROSPERO (https://www.crd.york.ac.uk/PROSPERO/), identifier: CRD42021265735.

Abstract licence: CC BY 4.0

AbstractPurposeTo evaluate the efficacy and safety of 1565‐nm nonablative fractional laser (NAFL) combined with mucopolysaccharide polysulfate (MPS) cream in the treatment of erythematous acne scars.MethodsA total of 28 subjects with erythematous acne scars from June 2021 to April 2022 were enrolled. One side of each subject's face was randomly assigned to be treated with 1565‐nm NAFL (at 2 sessions with four‐week intervals) combined with MPS cream (twice daily) for 8 weeks, and the other side with 1565‐nm NAFL combined with placebo cream. CBS® images and parameters, dermoscopic images and the quantitative data processed by ImageJ software, and quantitative global scarring grading system (GSS) score were obtained at baseline and after treatment. Subjects' satisfaction assessment was performed after treatment. Adverse events were recorded during treatment.ResultsIn CBS® parameters, the red area, red area concentration, and smoothness were improved more significantly on the 1565‐nm NAFL combined with MPS cream side than on the 1565‐nm NAFL combined with placebo cream side after treatment (p = 0.015, p = 0.013, and p = 0.021). For dermoscopy, both scar area and scar redness achieved a significantly greater percentage of improvement on the side of 1565‐nm NAFL combined with MPS cream than the side of 1565‐nm NAFL combined with placebo cream after treatment (p = 0.005 and p = 0.041). The reduction of quantitative GSS score and Subjects' satisfaction assessment were similarly superior on the 1565‐nm NAFL combined with MPS cream side. Temporary erythema was experienced by all subjects after each 1565‐nm NAFL treatment. No subject reported intolerance or allergy to the cream during follow‐up.ConclusionsThe combined application of 1565‐nm NAFL and MPS cream could be an effective and safe treatment for erythematous acne scars. ImageJ software enables quantitative evaluation of dermoscopic images of acne scars.

Abstract licence: CC BY 4.0

Secondary metabolites are highly beneficial to human health and have commercial and industrial values. So, this research aimed to study the effects of exogenous salicylic acid (SA) and jasmonic acid (JA) on some secondary metabolites in purple coneflower. A field experiment as a randomized complete block design with three replications was conducted in Shahrood, Iran. Treatments were the factorial arrangement of 3 SA (0, 0.5, and 1 millimole) and 4 JA concentrations (0, 5, 20, and 50 micromole). The non-linear regression procedure was employed to quantify the relation of these materials with each other. The results indicated that the SA effect on all ten measured secondary metabolites changed with changing the JA levels as there was the interaction between these elicitors. On average, most (7 out of 11) of the combined SA_JA levels up-regulated the production of secondary metabolites as compared to the plants not sprayed with SA and JA. In terms of average response to elicitation with 11 combined SA_JA levels, they ranked from higher to lower as the guaiacol peroxidase, hydrogen proxide (H2O2), polyphenol oxidase, glutathione S-transferase, superoxide dismutase, NADPH oxidase, total phenolic content, phenylalanine ammonia-lyase, anthocyanin, and flavonoid. A few secondary metabolites appeared to have a biphasic relationship with each other. For instance, over lower and medium values of NADPH oxidase activity, anthocyanin content increased linearly with increasing NADPH oxidase activity; over higher values of NADPH oxidase activity, it showed a plateau state.

Abstract licence: CC BY