Salicylic acid 1% / Lactic acid 2% in Generic Unguentum M cream

Objective To compare the efficacy of 20% zinc oxide paste versus 15% salicylic acid-15% lactic acid combination in treatment of common viral warts.   Methods In this randomized controlled trial, 210 patients suffering from common warts for more than three months duration were enrolled. These patients were randomly divided into two groups A and B; having 105 each. Group A patients were treated with topical 20% zinc oxide paste, whereas group B were treated with 15% salicylic-15% lactic acid combination. Patients were instructed to apply medication for 15 minutes, let it dry and then rub the wart with an emery stone before the next application. Patients were reviewed monthly for a period of three months to examine the change in number and size of warts. Efficacy of treatment was defined as more than 50% decrease in size of common warts at the end of 3 months of therapy.   Results Efficacy was achieved in 65 (61.9%) patients of group B (15% salicylic acid-15% lactic acid combination) as compared to 48 (45.7%) patients group A (20 % zinc oxide paste), which was statistically significant (p< 0.05).   Conclusion Topically applied 15% salicylic acid-15% lactic acid combination is superior in efficacy to 20% zinc oxide paste in treatment of common viral warts.    

Abstract licence: CC BY 4.0

The global market for alpha-hydroxy acids (AHAs) is undergoing significant expansion, propelled by increasing demand for skincare products that address aging and environmental damage. This review focuses on the dermatological applications of AHAs, particularly in cosmetic formulations like chemical peels. We have identified that AHAs, such as glycolic and lactic acids, enhance skin rejuvenation by promoting apoptosis in skin cells, boosting collagen and elastin synthesis, and improving skin texture and luminosity. Our comprehensive analysis reveals a nuanced understanding of AHAs' effectiveness across various skin types and conditions, demonstrating their broad utility in treating conditions like acne, hyperpigmentation, and photoaging. However, the optimal concentrations for therapeutic efficacy with minimal side effects are yet to be precisely defined, necessitating further research. Regulatory compliance is underscored as essential for the safe application of AHAs in cosmetics, with international guidelines recommending specific concentrations and pH levels to minimize potential skin irritation. In Conclusion, the review highlights the effectiveness of AHAs in cosmetic dermatology, emphasizing the necessity for continued research and rigorous regulatory adherence to maximize their safe and beneficial application worldwide.

Abstract licence: CC BY-NC