Protirelin 200micrograms/2ml solution for injection ampoules
Protirelin is the pharmaceutically available synthetic analogue of the endogenous peptide thyrotropin-releasing hormone (TRH).
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Protirelin
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Protirelin
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
3 branded products available
MHRA licensed products
View all licensed products for Protirelin on the MHRA register
Protirelin 200micrograms/2ml solution for injection ampoules
Protirelin 200micrograms/2ml solution for injection ampoules
Alliance Healthcare (Distribution) Ltd
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Check stock at pharmacies and supply information
Pharmacy stock checkers
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Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 2 · 1974–2026
Showing the 50 most relevant studies, sorted by most relevant.
L. Marangell, M. George, A. Callahan, et al.
Archives of general psychiatry, 1997
- Hospitalization
- Injections, Spinal
- Cross-Over Studies
Carsten Kirkegaard, N. Nørlem, Lauridsen Ub, et al.
Archives of general psychiatry, 1975
Peter T. Loosen
Archives of General Psychiatry, 1979
S. C. Miller, Jordan E. Warnick
Archives of neurology, 1989
- Spinal Cord
- Rats
- Amyotrophic Lateral Sclerosis
Shohei Okusa, Toshiki Tezuka, Jin Nakahara, et al.
Parkinsonism & Related Disorders, 2026
- Spinocerebellar Degenerations
- Thyrotropin-Releasing Hormone
- Outcome Assessment, Health Care
F. Duval, M. Mokrani, A. Erb, et al.
Psychoneuroendocrinology, 2017
- Suicide, Attempted
- Violence
- Hypothalamus
R. Anders, H. Merkle, W. Schurr, et al.
Journal of pharmaceutical sciences, 1983
A. Winokur, J. Amsterdam, J. Oler, et al.
Archives of general psychiatry, 1983
L. Angelucci, G. Lorentz, S. Maccari, et al.
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna, 1990
F. Duval, J. Macher, M. Mokrani
Archives of general psychiatry, 1990
- Circadian Rhythm
- Thyrotropin-Releasing Hormone
- Body Weight
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
Not available
Food interactions
2 warnings
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Although not currently available in any FDA-approved product, protirelin is a component of the TRH Test where it is used to test the response of the anterior pituitary gland in conditions such as secondary hypothyroidism and acromegaly.
Known interactions with other medicines. Always consult a healthcare professional.
Showing 50 of 193 interactions
Proteins and enzymes this drug interacts with in the body
ATC V04CJ02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Protirelin
Additional database identifiers
Drugs Product Database (DPD)
2198
ChemSpider
554166
BindingDB
50072394
ZINC
ZINC000004096261
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12299
GeneCards
TRHR
Guide to Pharmacology
363
UniProt Accession
TRFR_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite:
- DrugBank 6.02024Recommended citationKnox C., Wilson M., Klinger C.M., et alDrugBank 6.0: the DrugBank Knowledgebase for 2024Nucleic Acids Res. 2024 Jan 552(D1):D1265-D1275
- DrugBank 5.02018Wishart D.S., Feunang Y.D., Guo A.C., et alDrugBank 5.0: a major update to the DrugBank database for 2018Nucleic Acids Res. 2017 Nov 846(D1):D1074-D1082
- DrugBank 4.02014Law V., Knox C., Djoumbou Y., et alDrugBank 4.0: shedding new light on drug metabolismNucleic Acids Res. 2014 Jan 142(1):D1091-7
- DrugBank 3.02011Knox C., Law V., Jewison T., et alDrugBank 3.0: a comprehensive resource for 'omics' research on drugsNucleic Acids Res. 2011 Jan39(Database issue):D1035-41
- DrugBank 2.02008Wishart D.S., Knox C., Guo A.C., et alDrugBank: a knowledgebase for drugs, drug actions and drug targets.Nucleic Acids Research2008 Jan36(Database issue):D901-6
- DrugBank 1.02006Wishart D.S., Knox C., Guo A.C., et alDrugBank: a comprehensive resource for in silico drug discovery and exploration.Nucleic Acids Research2006 Jan 134(Database issue):D668-72