Propylthiouracil 100mg suppositories
Requires a prescription from a doctor or prescriber
A thiourea antithyroid agent.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Propylthiouracil
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
View EudraVigilance report
Suspected adverse reactions reported for Propylthiouracil
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity is based on WHO Anatomical Therapeutic Chemical (ATC) classification and on a factual NHS dm+d therapeutic-grouping code prefix. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Guidelines from the National Institute for Health and Care Excellence
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & safety information
Official UK regulator monitoring and safety alerts
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. Shortage and safety information sourced from MHRA drug safety updates (gov.uk, Crown Copyright under OGL v3.0).
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF code shown is the factual mapping value distributed by NHS Business Services Authority (NHSBSA) in the dm+d supplementary file under OGL v3.0; it is not affiliated with, nor licensed from, the publishers of the British National Formulary. ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Academic studies and reviews for this medicine's active substance
Showing the 50 most relevant studies.
Reviews & meta-analyses: 9 · Randomised trials: 1 · 1963–2023
Showing the 50 most relevant studies, sorted by most relevant.
Yue Liu, Qianqian Li, Yang Xu, et al.
PLOS ONE, 2023
Rongjing Song, Hepu Lin, Yue Chen, et al.
PLoS ONE, 2017
Beverly J. Tepper
The American Journal of Human Genetics, 1998
- Feeding Behavior
- Food Preferences
- Propylthiouracil
R. Hackmon, M. Blichowski, G. Koren
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2012
S. Bonnema, F. N. Bennedbæk, A. Veje, et al.
The Journal of clinical endocrinology and metabolism, 2004
K. Williams, Sunil Nayak, D. Becker, et al.
The Journal of clinical endocrinology and metabolism, 1997
- Chemical and Drug Induced Liver Injury
- Endocrinology
- Liver Diseases
B. Tepper, E. White, Yvonne Koelliker, et al.
Annals of the New York Academy of Sciences, 2009
- Food Preferences
- Genetic Variation
- Propylthiouracil
Bernd Bufe, Paul Breslin, Christina Kühn, et al.
Current Biology, 2005
- Phenylthiourea
- Propylthiouracil
- Genetic Variation
Daigo Nakazawa, Utano Tomaru, Akira Suzuki, et al.
Arthritis & Rheumatism, 2012
- Antimetabolites
- Carcinogens
- Deoxyribonuclease I
Valerie B. Duffy, Andrew C. Davidson, Judith R. Kidd, et al.
Alcoholism Clinical and Experimental Research, 2004
- Taste Receptors, Type 2
- Alcohol Drinking
- Analysis of Variance
Sources: aggregated from Europe PMC (EMBL-EBI), OpenAlex, Crossref, PubMed and other open scholarly databases. Retracted articles are excluded. Study information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
77 found
Half-life
2 hours
Mechanism
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine.
Food interactions
1 warning
Human targets
2 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Half-life
2 hours
Protein binding
82%
Elimination
35%
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 825 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:12586771 PMID:32718224 PMID:18821722
Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) .
PMID:32718224 PMID:18821722 PMID:12586771 PMID:18339710
Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3) via inner-ring deiodination (IRD) .
PMID:32718224
Catalyzes the deiodination of T3 to 3,3'-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3'-T2 to 3-T1 via IRD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'-diiodothyronamine .
PMID:18339710
Catalyzes the phenolic ring deiodination of 3,3'-diiodothyronamine and tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (By similarity). Catalyzes the deiodination of L-thyroxine sulfate and 3,3',5-triiodo-L-thyronine sulfate via IRD and of 3,3',5'-triiodo-L-thyronine sulfate via ORD (By similarity)
Enzymes involved in drug metabolism — important for understanding drug interactions
ATC H03BA02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Propylthiouracil
Additional database identifiers
Drugs Product Database (DPD)
9439
ChemSpider
571424
BindingDB
50133597
PDB
3CJ
ZINC
ZINC000004640636
HUGO Gene Nomenclature Committee (HGNC)
HGNC:12015
GenAtlas
TPO
GeneCards
TPO
GenBank Gene Database
J02969
GenBank Protein Database
339867
Guide to Pharmacology
2526
UniProt Accession
PERT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2883
GeneCards
DIO1
UniProt Accession
IOD1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:7218
GenAtlas
MPO
GeneCards
MPO
GenBank Gene Database
J02694
GenBank Protein Database
189040
Guide to Pharmacology
2789
UniProt Accession
PERM_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2689
GenAtlas
DBH
GeneCards
DBH
GenBank Gene Database
X13255
GenBank Protein Database
30474
Guide to Pharmacology
2486
UniProt Accession
DOPO_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:2595
GeneCards
CYP1A1
GenBank Gene Database
K03191
GenBank Protein Database
181276
Guide to Pharmacology
1318
UniProt Accession
CP1A1_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications:
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Structured knowledge from the free knowledge base
ATC classifications (Wikidata)
Linked open data from Wikidata (Q377342), a free and open knowledge base operated by the Wikimedia Foundation. Data is available under the Creative Commons CC0 1.0 Public Domain Dedication. WHO INN from the World Health Organization.