Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Requires a prescription from a doctor or prescriber
Phenoxymethylpenicillin is a narrow spectrum antibiotic also commonly referred to as Penicillin V or Penicillin VK.[A178609] It is a phenoxymethyl analog of Penicillin G, or [benzylpenicillin].
Safety information for pregnancy and breastfeeding
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Phenoxymethylpenicillin
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Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Phenoxymethylpenicillin
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
16 branded products available
MHRA licensed products
View all licensed products for Phenoxymethylpenicillin on the MHRA register
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
Phenoxymethylpenicillin 125mg/5ml oral solution sugar free
This is the NHS Drug Tariff indicative price used for reimbursement purposes. It may not reflect the price paid by patients or pharmacies.
View full Drug TariffSource: NHS Drug Tariff via NHSBSA. Derived from dm+d VMPP (Virtual Medicinal Product Pack) pricing data. Contains public sector information licensed under the Open Government Licence v3.0.
WHO defined daily dose (DDD)
2 gram
Not a recommended dose. The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults. It is a statistical measure used for research and comparison purposes only.
Source: WHO Collaborating Centre for Drug Statistics Methodology, distributed via NHS dm+d BNF mapping files. Contains public sector information licensed under the Open Government Licence v3.0.
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Phenoxymethylpenicillin
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(13)
Sore throat (acute): antimicrobial prescribing (NG84)
Sinusitis (acute): antimicrobial prescribing (NG79)
Acute respiratory infection in over 16s: initial assessment and management including virtual wards (hospital at home) (QS210)
Human and animal bites: antimicrobial prescribing (NG184)
Impetigo: antimicrobial prescribing (NG153)
Otitis media (acute): antimicrobial prescribing (NG91)
Cellulitis and erysipelas: antimicrobial prescribing (NG141)
Prostatitis (acute): antimicrobial prescribing (NG110)
Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing (NG114)
Leg ulcer infection: antimicrobial prescribing (NG152)
Pyelonephritis (acute): antimicrobial prescribing (NG111)
Clostridium difficile infection: risk with broad-spectrum antibiotics (ESMPB1)
Rapid tests for group A streptococcal infections in people with a sore throat (HTG531)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
30 minutes
Mechanism
Phenoxymethylpenicillin inhibits the biosynthesis of cell wall mucopeptide [labe…
Food interactions
1 warning
Human targets
1 target
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
25 to 60%
[A178612]…
Half-life
30 minutes
[L6412]
Protein binding
50-80%
Volume of distribution
35.4 L
Metabolism
35-70%
Elimination
25%
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Phenoxymethylpenicillin may be used for the treatment of:
- mild to moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas caused by Streptococcus without bacteremia
- mild to moderately severe infections of the respiratory tract caused by Pneumococcus
- mild infections of the skin and soft tissues caused by penicillin G-sensitive Staphylococcus
- mild to moderately severe infections of the oropharynx caused by Fusospirochetosis, including Vincent’s gingivitis and pharyngitis, usually respond to oral penicillin therapy
Off-label
Indicated for use as prophylaxis against bacterial endocarditis in patients with congenital heart disease or rheumatic or other acquired valvular heart disease when they undergo dental procedures and surgical procedures of the upper respiratory tract.[label]
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 194 interactions
[L6418]
Severe hypersensitivity reactions, often leading to death, have been reported with penicillin therapies.[label] Although phenoxymethylpenicillin was shown to be excreted in human breast milk, the use of this drug in pregnant or nursing women is regarded generally safe.
[L6415]
How the body processes this drug — absorption, distribution, metabolism, and elimination
[A178612]
The bioavailability of phenoxymethylpenicillin ranges from 25 to 60%.
[A178618]
Compared to the free acid form of the drug, the calcium or potassium salts of phenoxymethylpenicillin displays better absorption profiles. It is reported that fasting state enhances the drug absorption. The peak plasma concentrations of 200 to 700 ng/mL are achieved in 2 hours following an oral dose of 125 mg.
Following an oral dose of 500 mg, the peak plasma concentrations of 3 to 5 μg/mL are reached in 30 to 60 minutes post-dose.
[L6412]
[L6412]
[A178615]
Small amounts of the drug can be found in various tissues, with the highest amount found in the kidneys, with lesser amounts in the liver, skin, and intes tines. Phenoxymethylpenicillin was found in the cerebrospinal fluid.[label] Phenoxymethylpenicillin was detectable in the placenta and human breast milk.
[L6412]
Proteins and enzymes this drug interacts with in the body
PMID:15521010 PMID:18367661 PMID:19685173 PMID:26320580 PMID:7896779 PMID:8914574 PMID:9835627
Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system PMID:15521010 PMID:9835627
ATC J01CR50
ATC J01CE10
ATC J01CE02
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Phenoxymethylpenicillin
Additional database identifiers
Drugs Product Database (DPD)
8426
Drugs Product Database (DPD)
8428
Drugs Product Database (DPD)
8410
ChemSpider
6607
BindingDB
50370584
PDB
PNV
ZINC
ZINC000003831282
GenBank Gene Database
X52593
GenBank Protein Database
46611
UniProt Accession
Q53707_STAAU
GenBank Gene Database
BA000016
GenBank Protein Database
18145626
UniProt Accession
PBPA_CLOPE
GenBank Gene Database
X59460
GenBank Protein Database
41216
UniProt Accession
DACB_ECOLI
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10920
GenAtlas
SLC15A1
GeneCards
SLC15A1
GenBank Gene Database
U13173
GenBank Protein Database
773588
Guide to Pharmacology
984
UniProt Accession
S15A1_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: