Pegademase 375units/1.5ml solution for injection vials

Non-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression .
PMID:11726515 PMID:37626338
Thus, participates in many biological processes including regulation of innate and adaptive immunity, autophagy, DNA repair or necroptosis .
PMID:35831301 PMID:37626338 PMID:38182563

Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells .
PMID:36864087 PMID:9489702
Mechanistically, engagement of the TCR leads to phosphorylation of the adapter protein LAT, which serves as docking site for GRB2 .
PMID:9489702
In turn, GRB2 establishes a a connection with SOS1 that acts as a guanine nucleotide exchange factor and serves as a critical regulator of KRAS/RAF1 leading to MAPKs translocation to the nucleus and activation .
PMID:12171928 PMID:25870599
Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) .
PMID:25413232 PMID:29523808
Plays a role in switching between autophagy and programmed necrosis upstream of EGFR by interacting with components of necrosomes including RIPK1 and with autophagy regulators SQSTM1 and BECN1 .
PMID:35831301 PMID:38182563
Regulates miRNA biogenesis by forming a functional ternary complex with AGO2 and DICER1 .
PMID:37328606
Functions in the replication stress response by protecting DNA at stalled replication forks from MRE11-mediated degradation. Mechanistically, inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks .
PMID:38459011
Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process PMID:34348893