Papaverine 30mg/1ml solution for injection vials
Requires a prescription from a doctor or prescriber
An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions.
Official documents, adverse reaction reporting, and safety monitoring
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Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Papaverine
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Interactive Drug Analysis Profiles for all medicines
Report a side effect
Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Papaverine
About EudraVigilance
Learn about EU pharmacovigilance and safety monitoring
EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Papaverine
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
Browse tools
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA). ATC codes from the WHO Collaborating Centre for Drug Statistics Methodology (whocc.no).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
9 found
Half-life
0.5-2 hours
Mechanism
Perhaps by its direct vasodilating action on cerebral blood vessels, Papaverine…
Food interactions
None known
Human targets
5 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Half-life
0.5-2 hours
Protein binding
90%
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
Known interactions with other medications. Always consult a healthcare professional.
Showing 50 of 642 interactions
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:15260978
May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
PMID:15489334 PMID:9714779
Specifically regulates nitric-oxide-generated cGMP PMID:15489334
PMID:10373451 PMID:10393245 PMID:16330539 PMID:17389385 PMID:27058447
Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate .
PMID:10373451 PMID:10393245 PMID:17389385 PMID:27058447
May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition PMID:27058447
PMID:15260978 PMID:8855339 PMID:9419816
Has a preference for cGMP as a substrate PMID:9419816
ATC G04BE02
ATC A03AD01
ATC G04BE52
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Papaverine
Additional database identifiers
Drugs Product Database (DPD)
6941
Drugs Product Database (DPD)
2957
ChemSpider
4518
BindingDB
14754
PDB
EV1
ZINC
ZINC000000056555
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8781
GenAtlas
PDE4B
GeneCards
PDE4B
GenBank Gene Database
L20966
GenBank Protein Database
347122
Guide to Pharmacology
1301
UniProt Accession
PDE4B_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8783
GenAtlas
PDE4D
GeneCards
PDE4D
GenBank Gene Database
L20970
GenBank Protein Database
347130
Guide to Pharmacology
1303
UniProt Accession
PDE4D_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8784
GenAtlas
PDE5A
GeneCards
PDE5A
GenBank Gene Database
AF043731
GenBank Protein Database
3420185
Guide to Pharmacology
1304
UniProt Accession
PDE5A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8772
GenAtlas
PDE10A
GeneCards
PDE10A
GenBank Gene Database
AB020593
GenBank Protein Database
4958858
Guide to Pharmacology
1310
UniProt Accession
PDE10_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8783
GenAtlas
PDE4D
GeneCards
PDE4D
GenBank Gene Database
L20970
GenBank Protein Database
347130
Guide to Pharmacology
1303
UniProt Accession
PDE4D_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8779
GenAtlas
PDE3B
GeneCards
PDE3B
GenBank Gene Database
U38178
GenBank Protein Database
1145302
Guide to Pharmacology
1299
UniProt Accession
PDE3B_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8784
GenAtlas
PDE5A
GeneCards
PDE5A
GenBank Gene Database
AF043731
GenBank Protein Database
3420185
Guide to Pharmacology
1304
UniProt Accession
PDE5A_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8775
GenAtlas
PDE1B
GeneCards
PDE1B
GenBank Gene Database
U56976
Guide to Pharmacology
1295
UniProt Accession
PDE1B_HUMAN
International reference pricing
Reference pricing from DrugBank. Prices are indicative and may not reflect current UK costs.
Source: DrugBank. Used under CC BY-NC 4.0 academic licence for non-commercial purposes.
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: