Ornithine powder
Produced during the urea cycle, ornithine is an amino acid produced from the splitting off of urea from arginine.
Official documents, adverse reaction reporting, and safety monitoring
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Official medicine documents
Safety monitoring data
Yellow Card reports
The MHRA Yellow Card scheme collects reports of suspected side effects from healthcare professionals and patients. View the Drug Analysis Profile (iDAP) for real-world adverse reaction data.
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Suspected adverse reactions reported for Ornithine
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Submit a Yellow Card report to the MHRA
Data from the MHRA Yellow Card scheme. A reported reaction does not necessarily mean the medicine caused it. Contains public sector information licensed under the Open Government Licence v3.0.
EudraVigilance
The European Medicines Agency (EMA) collects suspected adverse reaction reports from across the EU/EEA through the EudraVigilance system. Search for safety data on this medicine.
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Suspected adverse reactions reported for Ornithine
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EudraVigilance data is published by the European Medicines Agency (EMA). A suspected adverse reaction is not necessarily caused by the medicine.
1 branded products available
Therapeutically similar medicines
Similarity based on WHO Anatomical Therapeutic Chemical (ATC) classification and NHS BNF section grouping. Source data: NHS dm+d via TRUD (OGL v3.0), WHO ATC/DDD Index.
NHS prescribing volume and spending trends
Clinical guidelines and formulary information
British National Formulary
Ornithine
Source: British National Formulary, NICE. Joint Formulary Committee. Contains public sector information licensed under the Open Government Licence v3.0.
NICE clinical guidance(1)
Source: National Institute for Health and Care Excellence (NICE). Contains public sector information licensed under the Open Government Licence v3.0.
Check stock at pharmacies and supply information
Pharmacy stock checkers
Search for this medicine at major UK pharmacy chains. These links open the retailer's own website — results depend on their current online catalogue.
Supply & product information
Official product databases and supply status monitoring
Pharmacy links redirect to the retailer's own search and do not represent real-time stock levels. emc (electronic medicines compendium) is operated by Datapharm Ltd. Shortage information sourced from NHS Specialist Pharmacy Service (SPS), sps.nhs.uk.
Codes for healthcare professionals and prescribing systems
These codes are used by healthcare IT systems and prescribers to identify this medicine.
NHS UK identifiers
SNOMED CT and dm+d codes from NHS TRUD (Technology Reference data Update Distribution), licensed under the Open Government Licence v3.0. BNF codes from NHS Business Services Authority (NHSBSA).
Active and completed clinical studies from ClinicalTrials.gov
Source: ClinicalTrials.gov, a database of the U.S. National Library of Medicine (NLM), National Institutes of Health (NIH). Data accessed via ClinicalTrials.gov API v2. Trial information is provided for research purposes and does not constitute medical advice.
Pharmacology and chemical data from DrugBank
Key facts
Drug status
Approved
Major interactions
None known
Half-life
Not available
Mechanism
L-Ornithine is metabolised to L-arginine.
Food interactions
None known
Human targets
10 targets
Data: DrugBank · CC BY-NC 4.0
Pharmacokinetics at a glance
Absorption
Metabolism
Pharmacokinetic data: DrugBank · CC BY-NC 4.0
How the body processes this drug — absorption, distribution, metabolism, and elimination
Proteins and enzymes this drug interacts with in the body
PMID:2556444 PMID:6372096 PMID:8112735
The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion PMID:2556444
PMID:17900240 PMID:26305948 PMID:26443277
Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC .
PMID:26305948
Stabilizes AZIN2 by interfering with its ubiquitination .
PMID:17900240
Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol PMID:12097147
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
Involved compounds
ATC A05BA06
Chemical identifiers
CAS, UNII, InChI Key and database cross-references
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Chemical identifiers
CAS, UNII, InChI Key and database cross-references
Linked compound data from DrugBank Open Data (CC BY-NC 4.0)
Ornithine
Additional database identifiers
Drugs Product Database (DPD)
1820
Drugs Product Database (DPD)
11709
ChemSpider
6026
BindingDB
50487430
PDB
ORN
Guide to Pharmacology
725
ZINC
ZINC000001532530
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8091
GenAtlas
OAT
GeneCards
OAT
GenBank Gene Database
M12267
GenBank Protein Database
189329
UniProt Accession
OAT_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8512
GenAtlas
OTC
GeneCards
OTC
GenBank Gene Database
K02100
GenBank Protein Database
189407
UniProt Accession
OTC_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:663
GenAtlas
ARG1
GeneCards
ARG1
GenBank Gene Database
M14502
GenBank Protein Database
178995
Guide to Pharmacology
1244
UniProt Accession
ARGI1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:8095
GenAtlas
OAZ1
GeneCards
OAZ1
GenBank Gene Database
U09202
GenBank Protein Database
852429
UniProt Accession
OAZ1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11057
GenAtlas
SLC7A1
GeneCards
SLC7A1
GenBank Gene Database
X59155
GenBank Protein Database
36161
UniProt Accession
CTR1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:11060
GenAtlas
SLC7A2
GeneCards
SLC7A2
GenBank Gene Database
D29990
GenBank Protein Database
849051
UniProt Accession
CTR2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:22921
GenAtlas
SLC25A2
GeneCards
SLC25A2
GenBank Gene Database
AF332005
GenBank Protein Database
13445628
UniProt Accession
ORNT2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:664
GenAtlas
ARG2
GeneCards
ARG2
GenBank Gene Database
D86724
GenBank Protein Database
1694633
Guide to Pharmacology
1245
UniProt Accession
ARGI2_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:10985
GenAtlas
SLC25A15
GeneCards
SLC25A15
GenBank Gene Database
AF112968
GenBank Protein Database
5565862
UniProt Accession
ORNT1_HUMAN
HUGO Gene Nomenclature Committee (HGNC)
HGNC:4175
GenAtlas
GATM
GeneCards
GATM
GenBank Gene Database
S68805
GenBank Protein Database
545385
UniProt Accession
GATM_HUMAN
DrugBank citations
If you use DrugBank data in your research, please cite the following publications: