Oleic acid liquid

BackgroundOleic acid, a monounsaturated fatty acid (MUFA), exhibits beneficial properties in healthy subjects. However, it remains unclear whether these favorable effects extend to metabolically unhealthy individuals. Therefore, this study aimed to investigate the effect of an oleic acid-enriched oil formula on metabolic health outcomes.MethodsOur comprehensive systematic search was conducted in the following databases: PubMed, Scopus, Web of Science, and Google Scholar based on PRISMA guideline. The random-effect model was used to pool standardized mean differences (SMD).ResultsFifteen eligible studies met our inclusion criteria and were included in our systematic review and meta-analysis. Data analysis indicated that oleic acid consumption is not associated with improvement of lipid markers including total cholesterol (TC), low density lipoprotein cholesterol (LDL-c), high density lipoprotein cholesterol (HDL-c), and triglyceride (TG). In addition, it has been shown that subgroup analysis based on the BMI of participants, intervention duration, and oleic acid content could not modify the response to oleic acid intervention in term of lipid profile. Moreover, combined effect of studies evaluating the effect of the oleic acid on the glycemic control, obesity measures, and blood pressure illustrated that oleic acid is not potent enough to affect them in unhealthy individuals.ConclusionThe current meta-analysis indicated that oleic acid intervention exerts population specific responses; despite its beneficial properties, oleic acid does not improve health outcomes in metabolically unhealthy individuals.

Abstract licence: CC BY

Dairy cows going through the transition period experience a state of negative energy balance, driven by a mismatch between rising energy needs and reduced feed intake. Although fat breakdown (i.e., lipolysis) is a necessary adaptation to meet rising energy demands, excessive and prolonged lipolysis can increase disease risk. One strategy to mitigate this gap in energy is by increasing the energy density of the diet through fatty acid (FA) supplementation. Among available FA, oleic acid (OA) has gained attention not only as an energy source, but also for its broader biological effects. This review examines the role of OA in dairy cow metabolism, extending beyond its caloric contribution to its regulatory influence on lipid metabolism, insulin signaling, oxidative stress, and inflammation. We summarize findings from both ruminants and nonruminants to provide mechanistic insights into how OA modulates cellular pathways and contributes to metabolic adaptations, especially within adipose tissue during periods of physiological stress. Additionally, we highlight the nutritional implications of OA on production outcomes such as milk yield and composition, as well as its effects on adipose tissue. By integrating nutritional and mechanistic perspectives, this review provides a comprehensive evaluation of OA potential as a functional nutrient to support health and performance in transition dairy cows.

Abstract licence: CC BY